Proteomics and kidney stone disease
Kidney stone disease (nephrolithiasis) is an ancient and common affliction. It has been recognized for a long time with evidence of stone found in ∼7,000-year-old mummies and remains a common problem worldwide, indicating ineffective prevention in the past. Precise pathogenic and molecular mechanism...
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th-mahidol.195722018-07-12T09:39:45Z Proteomics and kidney stone disease V. Thongboonkerd Mahidol University Faculty of Medicine, Siriraj Hospital, Mahidol University Medicine Kidney stone disease (nephrolithiasis) is an ancient and common affliction. It has been recognized for a long time with evidence of stone found in ∼7,000-year-old mummies and remains a common problem worldwide, indicating ineffective prevention in the past. Precise pathogenic and molecular mechanisms of kidney stone formation are still poorly understood and should be further elucidated. Also, identification of novel therapeutic targets for better therapeutic outcome and successful prevention of the occurrence and recurrence of the stone are crucially required. One of the most promising tools for current and future biomedical research is proteomics, which has been extensively and widely applied to the nephrology field during the past 5 years. Its high-throughput capability holds a great promise also to kidney stone research. This chapter provides a brief overview of proteomic methodologies recently used for the investigation of nephrolithiasis and recent proteomic studies of nephrolithiasis are summarized. Copyright © 2008 S. Karger AG. 2018-07-12T02:39:45Z 2018-07-12T02:39:45Z 2008-08-20 Review Contributions to Nephrology. Vol.160, (2008), 142-158 10.1159/000125972 03025144 2-s2.0-48949095632 https://repository.li.mahidol.ac.th/handle/123456789/19572 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=48949095632&origin=inward |
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Kidney stone disease (nephrolithiasis) is an ancient and common affliction. It has been recognized for a long time with evidence of stone found in ∼7,000-year-old mummies and remains a common problem worldwide, indicating ineffective prevention in the past. Precise pathogenic and molecular mechanisms of kidney stone formation are still poorly understood and should be further elucidated. Also, identification of novel therapeutic targets for better therapeutic outcome and successful prevention of the occurrence and recurrence of the stone are crucially required. One of the most promising tools for current and future biomedical research is proteomics, which has been extensively and widely applied to the nephrology field during the past 5 years. Its high-throughput capability holds a great promise also to kidney stone research. This chapter provides a brief overview of proteomic methodologies recently used for the investigation of nephrolithiasis and recent proteomic studies of nephrolithiasis are summarized. Copyright © 2008 S. Karger AG. |
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Proteomics and kidney stone disease |
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Proteomics and kidney stone disease |
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Proteomics and kidney stone disease |
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Proteomics and kidney stone disease |
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Proteomics and kidney stone disease |
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proteomics and kidney stone disease |
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2018 |
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