Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy
ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP f...
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th-mahidol.196582018-07-12T09:42:33Z Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy Noppadol Larbcharoensub Juvady Leopairat Ekaphop Sirachainan Ladawan Narkwong Thongchai Bhongmakapat Kawin Rasmeepaisarn Tavan Janvilisri Faculty of Medicine, Ramathibodi Hospital, Mahidol University Faculty of Medicine, Thammasat University Mahidol University Medicine ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential as prognostic indicators in patients with NPC. We examined the protein expression profiles of MDR1, MRP1, and BCRP in NPC tissues from 60 patients with advanced stages who were treated with radiotherapy and concurrent chemotherapy. The clinicopathologic features, patterns of treatment failure, and survival data were compared with the transporter expression. Univariate analyses were performed to determine the prognostic factors that influenced treatment failure and patient survival. We found that MRP1 expression was strongly predictive of both 5-year survival (P = .025) and disease-free survival (P < .001). However, neither MDR1 nor BCRP expression was correlated with the clinicopathologic parameters. Interestingly, the incidence of recurrence and metastasis for patients in the MRP1-positive group was significantly higher than that in the MRP1-negative group (P = .003). With multivariate analysis, MRP1 expression at the time of diagnosis before the treatment was identified as an independent prognostic factor for both 5-year survival (P = .041) and disease-free survival (P = .001). MRP1 expression can therefore be used as a potent molecular risk factor and a guide for chemotherapeutic regimens in patients with advanced stages of NPC. © 2008. 2018-07-12T02:42:33Z 2018-07-12T02:42:33Z 2008-06-01 Article Human Pathology. Vol.39, No.6 (2008), 837-845 10.1016/j.humpath.2007.10.009 00468177 2-s2.0-44649142102 https://repository.li.mahidol.ac.th/handle/123456789/19658 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=44649142102&origin=inward |
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Medicine Noppadol Larbcharoensub Juvady Leopairat Ekaphop Sirachainan Ladawan Narkwong Thongchai Bhongmakapat Kawin Rasmeepaisarn Tavan Janvilisri Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy |
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ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential as prognostic indicators in patients with NPC. We examined the protein expression profiles of MDR1, MRP1, and BCRP in NPC tissues from 60 patients with advanced stages who were treated with radiotherapy and concurrent chemotherapy. The clinicopathologic features, patterns of treatment failure, and survival data were compared with the transporter expression. Univariate analyses were performed to determine the prognostic factors that influenced treatment failure and patient survival. We found that MRP1 expression was strongly predictive of both 5-year survival (P = .025) and disease-free survival (P < .001). However, neither MDR1 nor BCRP expression was correlated with the clinicopathologic parameters. Interestingly, the incidence of recurrence and metastasis for patients in the MRP1-positive group was significantly higher than that in the MRP1-negative group (P = .003). With multivariate analysis, MRP1 expression at the time of diagnosis before the treatment was identified as an independent prognostic factor for both 5-year survival (P = .041) and disease-free survival (P = .001). MRP1 expression can therefore be used as a potent molecular risk factor and a guide for chemotherapeutic regimens in patients with advanced stages of NPC. © 2008. |
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Faculty of Medicine, Ramathibodi Hospital, Mahidol University |
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Faculty of Medicine, Ramathibodi Hospital, Mahidol University Noppadol Larbcharoensub Juvady Leopairat Ekaphop Sirachainan Ladawan Narkwong Thongchai Bhongmakapat Kawin Rasmeepaisarn Tavan Janvilisri |
format |
Article |
author |
Noppadol Larbcharoensub Juvady Leopairat Ekaphop Sirachainan Ladawan Narkwong Thongchai Bhongmakapat Kawin Rasmeepaisarn Tavan Janvilisri |
author_sort |
Noppadol Larbcharoensub |
title |
Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy |
title_short |
Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy |
title_full |
Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy |
title_fullStr |
Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy |
title_full_unstemmed |
Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy |
title_sort |
association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/19658 |
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1763488083935756288 |