Tumor necrosis factor alpha-mediated nitric oxide production enhances manganese superoxide dismutase nitration and mitochondrial dysfunction in primary neurons: an insight into the role of glial cells

• Main Authors: J. Tangpong, P. Sompol, M. Vore, W. St. Clair, D. A. Butterfield, D. K. St. Clair
• Other Authors: Walailak University
• Format: Article
• Published: 2018
• Subjects: Neuroscience
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/19856
• Institution: Mahidol University

Tumor necrosis factor-alpha (TNF-α), a ubiquitous pro-inflammatory cytokine, is an important mediator in the immune-neuroendocrine system that affects the CNS. The present study demonstrates that treatment with TNF-α activates microglia to increase TNF-α production in primary cultures of glial cells...