Synergistic cytotoxicity and apoptosis induced in human cholangiocarcinoma cell lines by a combined treatment with tumor necrosis factor-alpha (TNF-α) and triptolide

• Main Authors: Tasanee Panichakul, Thiwaree Wanun, Vichai Reutrakul, Stitaya Sirisinha
• Other Authors: Chulabhorn Research Institute
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/20199
• Institution: Mahidol University

Cholangiocarcinoma is known to be relatively resistant to chemotherapy. One alternative approach is to use a combination of an immunomodulating agent with an anticancer drug. Here we studied the synergistic actions of TNF-α and triptolide (a diterpene epoxide prepared from Tripterygium wilfordii), p...