Chimeric dengue type 2/type 1 viruses induce immune responses in cynomolgus monkeys

• Main Authors: Siritorn Butrapet, Jundee Rabablert, Subhkij Angsubhakorn, Witawat Wiriyarat, Claire Huang, Richard Kinney, Sakol Punyim, Natth Bhamarapravati
• Other Authors: Inst. Sci./Technol. for R. and D
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/20295
• Institution: Mahidol University

Chimeric dengue type 2/type 1 (DEN2/1) viruses, which contain the structural genes of the dengue-1 (16007) parental virus and the nonstructural genes of the DEN2-PDK53 virus, have been constructed. These DEN2/1 viruses induce high levels of DEN1 virus-specific neutralizing antibodies in mice. In thi...