Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand
A CCTTT microsatellite repeat in the inducible nitric oxide synthase (iNOS) promoter was analyzed among 256 adult patients with severe Plasmodium falciparum malaria and 179 adult patients with mild malaria living in northwestern Thailand. Genotypes with longer forms of the CCTTT repeat (alleles of ≥...
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th-mahidol.204082018-07-24T10:06:33Z Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand Jun Ohashi Izumi Naka Jintana Patarapotikul Hathairad Hananantachai Sornchai Looareesuwan Katsushi Tokunaga University of Tokyo Mahidol University Medicine A CCTTT microsatellite repeat in the inducible nitric oxide synthase (iNOS) promoter was analyzed among 256 adult patients with severe Plasmodium falciparum malaria and 179 adult patients with mild malaria living in northwestern Thailand. Genotypes with longer forms of the CCTTT repeat (alleles of ≥15 repeats) were significantly associated with severe malaria (odds ratio [OR], 2.14; P = .0029, X2test). More interestingly, the summed repeat number of both microsatellite alleles in an individual was found to be a significant risk factor for severe malaria (OR, 1.11; logistic regression analysis, P = .0041). The single nucleotide substitution, -954G→C, in the iNOS promoter was rare in Thai patients with malaria. No variations were detected in the iNOS promoter region containing functional NF-κB elements at -5.2, -5.5, -5.8, and -6.1 kb upstream of the iNOS transcriptional start site. Thus, a CCTTT repeat in the iNOS promoter may play a key role in the pathogenesis of severe malaria. 2018-07-24T03:06:33Z 2018-07-24T03:06:33Z 2002-08-15 Article Journal of Infectious Diseases. Vol.186, No.4 (2002), 578-581 10.1086/341779 00221899 2-s2.0-0037103603 https://repository.li.mahidol.ac.th/handle/123456789/20408 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037103603&origin=inward |
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Medicine Jun Ohashi Izumi Naka Jintana Patarapotikul Hathairad Hananantachai Sornchai Looareesuwan Katsushi Tokunaga Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand |
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A CCTTT microsatellite repeat in the inducible nitric oxide synthase (iNOS) promoter was analyzed among 256 adult patients with severe Plasmodium falciparum malaria and 179 adult patients with mild malaria living in northwestern Thailand. Genotypes with longer forms of the CCTTT repeat (alleles of ≥15 repeats) were significantly associated with severe malaria (odds ratio [OR], 2.14; P = .0029, X2test). More interestingly, the summed repeat number of both microsatellite alleles in an individual was found to be a significant risk factor for severe malaria (OR, 1.11; logistic regression analysis, P = .0041). The single nucleotide substitution, -954G→C, in the iNOS promoter was rare in Thai patients with malaria. No variations were detected in the iNOS promoter region containing functional NF-κB elements at -5.2, -5.5, -5.8, and -6.1 kb upstream of the iNOS transcriptional start site. Thus, a CCTTT repeat in the iNOS promoter may play a key role in the pathogenesis of severe malaria. |
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University of Tokyo |
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University of Tokyo Jun Ohashi Izumi Naka Jintana Patarapotikul Hathairad Hananantachai Sornchai Looareesuwan Katsushi Tokunaga |
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Article |
author |
Jun Ohashi Izumi Naka Jintana Patarapotikul Hathairad Hananantachai Sornchai Looareesuwan Katsushi Tokunaga |
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Jun Ohashi |
title |
Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand |
title_short |
Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand |
title_full |
Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand |
title_fullStr |
Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand |
title_full_unstemmed |
Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand |
title_sort |
significant association of longer forms of ccttt microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in thailand |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/20408 |
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1763491001351012352 |