Central role of the spleen in malaria parasite clearance
In acute malaria, red blood cells (RBCs) that have been parasitized, but no longer contain a malaria parasite, are found in the circulation (ring-infected erythrocyte surface antigen [RESA]-RBCs). These are thought to arise by splenic removal of dead or damaged intraerythrocytic parasites and return...
Saved in:
Main Authors: | , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Published: |
2018
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/20490 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.20490 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.204902018-07-24T10:08:35Z Central role of the spleen in malaria parasite clearance Kesinee Chotivanich Rachanee Udomsangpetch Rose McGready Stephane Proux Paul Newton Sasithon Pukrittayakamee Sornchai Looareesuwan Nicholas J. White Mahidol University Shoklo Malaria Research Unit University of Oxford Medicine In acute malaria, red blood cells (RBCs) that have been parasitized, but no longer contain a malaria parasite, are found in the circulation (ring-infected erythrocyte surface antigen [RESA]-RBCs). These are thought to arise by splenic removal of dead or damaged intraerythrocytic parasites and return of the intact RBCs to the circulation. In a study of 5 patients with acute falciparum malaria who had previously undergone splenectomy, it was found that none of these 5 patients had any circulating RESA-RBCs, in contrast to the uniform finding of RESA-RBCs in all patients with acute malaria and intact spleens. Parasite clearance after artesunate treatment was markedly prolonged, although the parasites appeared to be dead and could not be cultured ex vivo. These observations confirm the central role of the spleen in the clearance of parasitized RBCs after antimalarial treatment with an artemisinin derivative. Current criteria for high-grade antimalarial drug resistance that are based on changes in parasitemia are not appropriate for asplenic patients. © 2002 The Infectious Diseases Society of America. 2018-07-24T03:08:35Z 2018-07-24T03:08:35Z 2002-05-15 Article Journal of Infectious Diseases. Vol.185, No.10 (2002), 1538-1541 10.1086/340213 00221899 2-s2.0-0037094069 https://repository.li.mahidol.ac.th/handle/123456789/20490 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037094069&origin=inward |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Medicine |
spellingShingle |
Medicine Kesinee Chotivanich Rachanee Udomsangpetch Rose McGready Stephane Proux Paul Newton Sasithon Pukrittayakamee Sornchai Looareesuwan Nicholas J. White Central role of the spleen in malaria parasite clearance |
description |
In acute malaria, red blood cells (RBCs) that have been parasitized, but no longer contain a malaria parasite, are found in the circulation (ring-infected erythrocyte surface antigen [RESA]-RBCs). These are thought to arise by splenic removal of dead or damaged intraerythrocytic parasites and return of the intact RBCs to the circulation. In a study of 5 patients with acute falciparum malaria who had previously undergone splenectomy, it was found that none of these 5 patients had any circulating RESA-RBCs, in contrast to the uniform finding of RESA-RBCs in all patients with acute malaria and intact spleens. Parasite clearance after artesunate treatment was markedly prolonged, although the parasites appeared to be dead and could not be cultured ex vivo. These observations confirm the central role of the spleen in the clearance of parasitized RBCs after antimalarial treatment with an artemisinin derivative. Current criteria for high-grade antimalarial drug resistance that are based on changes in parasitemia are not appropriate for asplenic patients. © 2002 The Infectious Diseases Society of America. |
author2 |
Mahidol University |
author_facet |
Mahidol University Kesinee Chotivanich Rachanee Udomsangpetch Rose McGready Stephane Proux Paul Newton Sasithon Pukrittayakamee Sornchai Looareesuwan Nicholas J. White |
format |
Article |
author |
Kesinee Chotivanich Rachanee Udomsangpetch Rose McGready Stephane Proux Paul Newton Sasithon Pukrittayakamee Sornchai Looareesuwan Nicholas J. White |
author_sort |
Kesinee Chotivanich |
title |
Central role of the spleen in malaria parasite clearance |
title_short |
Central role of the spleen in malaria parasite clearance |
title_full |
Central role of the spleen in malaria parasite clearance |
title_fullStr |
Central role of the spleen in malaria parasite clearance |
title_full_unstemmed |
Central role of the spleen in malaria parasite clearance |
title_sort |
central role of the spleen in malaria parasite clearance |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/20490 |
_version_ |
1763489969090854912 |