Immunity to Malaria in plasmodium vivax infection: a study in central China
Background: P. vivax infection is characterised by relapsing fever, indicating reinfection by previously hidden parasites in the host. Relapsed infection can lead to the activation of the memory T cell pool, which may lead to protective immunity. This study aims to characterise immune responses in...
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th-mahidol.20662023-04-12T15:29:22Z Immunity to Malaria in plasmodium vivax infection: a study in central China Kulachart Jangpatarapongsa Hui Xia Qiang Fang Kaiming Hu Yuanying Yuan Meiyu Peng Qi Gao Jetsumon Sattabongkot Liwang Cui8, Baiqing Li Rachanee Udomsangpetch Center for Innovation Development and Technology Transfer Department of Clinical Microbiology and Applied Technology Department of Pathobiology Malaria Plasmodium vivax Infection China Background: P. vivax infection is characterised by relapsing fever, indicating reinfection by previously hidden parasites in the host. Relapsed infection can lead to the activation of the memory T cell pool, which may lead to protective immunity. This study aims to characterise immune responses in acute P. vivax-infected patients living in an area of central China characterised by only P. vivax infection. Methodology/Principal Findings: We conducted a cross-sectional immune-phenotypic analysis of adults using the following inclusion criteria: acute P. vivax infection (N = 37), a history of P. vivax infection (N = 17), and no known history of P. vivax infection (N = 21). We also conducted a 2-week longitudinal analysis following acute P. vivax infection, in which PBMC proliferation was measured in response to P. vivax and P. falciparum blood stage lysates. Using flow cytometry, we showed elevated memory T cells in the blood during acute P. vivax infection. The levels of cd T cells were two-fold higher than those measured in naive controls. This result suggested that in the two populations, memory and cd T cells promptly responded to P. vivax parasites. Interestingly, P. falciparum antigens stimulated T cells obtained from P. vivax-infected patients during a day 14-convalescence, whereas lymphocytes from the naı¨ve control group responded to a lower degree of convalescence. Conclusions/Significance: Cell-mediated immunity during the convalescent period of the P. vivax-infected hosts was comprised of T cells that were specifically able to recognise P. falciparum antigens. Although the magnitude of the response was only half that measured after stimulation with P. vivax antigens, the matter of cross-antigenic stimulation is of great interest. 2013-06-17T10:15:38Z 2017-06-20T16:08:13Z 2013-06-17T10:15:38Z 2017-06-20T16:08:13Z 2013-06-17 2012 Article Plos One. Vol.7, No.9 (2012), e45971 https://repository.li.mahidol.ac.th/handle/123456789/2066 eng Mahidol University application/pdf Mahidol University |
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Malaria Plasmodium vivax Infection China |
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Malaria Plasmodium vivax Infection China Kulachart Jangpatarapongsa Hui Xia Qiang Fang Kaiming Hu Yuanying Yuan Meiyu Peng Qi Gao Jetsumon Sattabongkot Liwang Cui8, Baiqing Li Rachanee Udomsangpetch Immunity to Malaria in plasmodium vivax infection: a study in central China |
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Background: P. vivax infection is characterised by relapsing fever, indicating reinfection by previously hidden parasites in
the host. Relapsed infection can lead to the activation of the memory T cell pool, which may lead to protective immunity.
This study aims to characterise immune responses in acute P. vivax-infected patients living in an area of central China
characterised by only P. vivax infection.
Methodology/Principal Findings: We conducted a cross-sectional immune-phenotypic analysis of adults using the
following inclusion criteria: acute P. vivax infection (N = 37), a history of P. vivax infection (N = 17), and no known history of P.
vivax infection (N = 21). We also conducted a 2-week longitudinal analysis following acute P. vivax infection, in which PBMC
proliferation was measured in response to P. vivax and P. falciparum blood stage lysates. Using flow cytometry, we showed
elevated memory T cells in the blood during acute P. vivax infection. The levels of cd T cells were two-fold higher than those
measured in naive controls. This result suggested that in the two populations, memory and cd T cells promptly responded
to P. vivax parasites. Interestingly, P. falciparum antigens stimulated T cells obtained from P. vivax-infected patients during a
day 14-convalescence, whereas lymphocytes from the naı¨ve control group responded to a lower degree of convalescence.
Conclusions/Significance: Cell-mediated immunity during the convalescent period of the P. vivax-infected hosts was
comprised of T cells that were specifically able to recognise P. falciparum antigens. Although the magnitude of the response
was only half that measured after stimulation with P. vivax antigens, the matter of cross-antigenic stimulation is of great
interest. |
author2 |
Center for Innovation Development and Technology Transfer |
author_facet |
Center for Innovation Development and Technology Transfer Kulachart Jangpatarapongsa Hui Xia Qiang Fang Kaiming Hu Yuanying Yuan Meiyu Peng Qi Gao Jetsumon Sattabongkot Liwang Cui8, Baiqing Li Rachanee Udomsangpetch |
format |
Article |
author |
Kulachart Jangpatarapongsa Hui Xia Qiang Fang Kaiming Hu Yuanying Yuan Meiyu Peng Qi Gao Jetsumon Sattabongkot Liwang Cui8, Baiqing Li Rachanee Udomsangpetch |
author_sort |
Kulachart Jangpatarapongsa |
title |
Immunity to Malaria in plasmodium vivax infection: a study in central China |
title_short |
Immunity to Malaria in plasmodium vivax infection: a study in central China |
title_full |
Immunity to Malaria in plasmodium vivax infection: a study in central China |
title_fullStr |
Immunity to Malaria in plasmodium vivax infection: a study in central China |
title_full_unstemmed |
Immunity to Malaria in plasmodium vivax infection: a study in central China |
title_sort |
immunity to malaria in plasmodium vivax infection: a study in central china |
publisher |
Mahidol University |
publishDate |
2013 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/2066 |
_version_ |
1781415631177908224 |