A single-nucleotide substitution from C to T at position - 1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand

• Main Authors: Juno Ohashi, I. Naka, J. Patarapotikul, H. Hananantachai, S. Looareesuwan, K. Tokunaga
• Other Authors: University of Tokyo
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/20689
• Institution: Mahidol University

We examined possible association of single-nucleotide polymorphisms (SNPs) in the promoters of IL-3, IL-4, and IL- 13 genes on the 5q31-33, IL-3 - 16T> C, IL-4 - 590T> C, and IL-13 - 1055C> T, with severity of malaria in 361 adult malaria patients in Thailand. The IL-13 - 1055T allele showe...