Upregulation of β<inf>1</inf>-adrenergic receptors in ovariectomized rat hearts

• Main Authors: Ariyaporn Thawornkaiwong, Surin Preawnim, Jonggonnee Wattanapermpool
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/20755

Changes in cardiac myofilament Ca2+activation have been demonstrated in ovariectomized rats. The underlying mechanisms responsible for these changes, however, are unknown. Accordingly, we measured both density and binding affinity of cardiac β1-adrenergic receptors in sarcolemmal preparations from 1...