Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy
Nutritional deficiency and malaria are 2 major causes of anaemia during pregnancy in tropical areas. The relationship between anaemia, its treatment with iron and folate, and malaria was studied in a prospective cohort of 2112 pregnant Karen women on the north-western border of Thailand between 1993...
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th-mahidol.209052018-07-24T10:25:13Z Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy Mathieu Nacher Rose McGready Kasia Stepniewska Thein Cho Sornchai Looareesuwan Nicholas J. White François Nosten Mahidol University Shoklo Malaria Research Unit Immunology and Microbiology Nutritional deficiency and malaria are 2 major causes of anaemia during pregnancy in tropical areas. The relationship between anaemia, its treatment with iron and folate, and malaria was studied in a prospective cohort of 2112 pregnant Karen women on the north-western border of Thailand between 1993 and 1997. The development of Plasmodium vivax malaria was associated with a past mean haematocrit, > 30% (hazard ratio = 1.5, 95% CI 1.2-2, P = 0.001) and recent (≤ 30 d) iron and folate supplementation (hazard ratio = 1.7, 95% CI 1.1-2.6, P= 0.01). There were no associations with P. falciparum infections. Plasmodium vivax has a predilection for young erythrocytes, and these results suggest that pregnant women with larger numbers of circulating young red cells are at greater risk of developing P. vivax malaria. In P. vivax-endemic areas, systematic iron and folate supplementation confers both benefit and risk in pregnancy. © 2003 Royal Society of Tropical Medicine and Hygiene. 2018-07-24T03:25:13Z 2018-07-24T03:25:13Z 2003-05-01 Article Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.97, No.3 (2003), 273-276 10.1016/S0035-9203(03)90140-4 00359203 2-s2.0-4444231687 https://repository.li.mahidol.ac.th/handle/123456789/20905 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=4444231687&origin=inward |
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Immunology and Microbiology Mathieu Nacher Rose McGready Kasia Stepniewska Thein Cho Sornchai Looareesuwan Nicholas J. White François Nosten Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy |
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Nutritional deficiency and malaria are 2 major causes of anaemia during pregnancy in tropical areas. The relationship between anaemia, its treatment with iron and folate, and malaria was studied in a prospective cohort of 2112 pregnant Karen women on the north-western border of Thailand between 1993 and 1997. The development of Plasmodium vivax malaria was associated with a past mean haematocrit, > 30% (hazard ratio = 1.5, 95% CI 1.2-2, P = 0.001) and recent (≤ 30 d) iron and folate supplementation (hazard ratio = 1.7, 95% CI 1.1-2.6, P= 0.01). There were no associations with P. falciparum infections. Plasmodium vivax has a predilection for young erythrocytes, and these results suggest that pregnant women with larger numbers of circulating young red cells are at greater risk of developing P. vivax malaria. In P. vivax-endemic areas, systematic iron and folate supplementation confers both benefit and risk in pregnancy. © 2003 Royal Society of Tropical Medicine and Hygiene. |
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Mahidol University |
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Mahidol University Mathieu Nacher Rose McGready Kasia Stepniewska Thein Cho Sornchai Looareesuwan Nicholas J. White François Nosten |
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Article |
author |
Mathieu Nacher Rose McGready Kasia Stepniewska Thein Cho Sornchai Looareesuwan Nicholas J. White François Nosten |
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Mathieu Nacher |
title |
Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy |
title_short |
Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy |
title_full |
Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy |
title_fullStr |
Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy |
title_full_unstemmed |
Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy |
title_sort |
haematinic treatment of anaemia increases the risk of plasmodium vivax malaria in pregnancy |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/20905 |
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1763494442398908416 |