Recrudescence in artesunate-treated patients with falciparum malaria is dependent on parasite burden not on parasite factors

• Main Authors: Wanida Ittarat, Amy L. Pickard, Panthip Rattanasinganchan, Polrat Wilairatana, Sornchai Looareesuwan, Kathryn Emery, Jonathan Low, Rachanee Udomsangpetch, Steven R. Meshnick
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/20931

Artemisinin derivatives are first-line antimalarial drugs in Thailand. No firm evidence of clinically relevant artemisinin resistance exists. When used as monotherapy, artesunate has been associated with a high treatment failure (recrudescence) rate, which could be due to low-level artemisinin resis...