Molecular modeling of the human hemoglobin-haptoglobin complex sheds light on the protective mechanisms of haptoglobin.

• Main Authors: Chanin Nantasenamat, Virapong Prachayasittikul, Leif Bulow
• Other Authors: Mahidol University. Faculty of Medical Technology
• Format: Article
• Language: English
• Published: Mahidol University 2014
• Subjects: Biochemistry simulations; Blood chemistry; Computational biology; Computational chemistry; Macromolecular assemblies; Macromolecular structure analysis; Molecular dynamics; Molecular mechanics; Protein interactions; Protein structure
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/2101
• Institution: Mahidol University

Hemoglobin (Hb) plays a critical role in human physiological function by transporting O2. Hb is safe and inert within the confinement of the red blood cell but becomes reactive and toxic upon hemolysis. Haptoglobin (Hp) is an acute-phase serum protein that scavenges Hb and the resulting Hb-Hp comple...