Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil
Objective: To determine the effects of late pregnancy and also oestrogen supplementation on the CYP2C19-mediated biotransformation of proguanil (PG) to its active antifol triazine metabolite cycloguanil (CG). Methods: Case control study conducted on the NW border of Thailand; a single dose of PG (4...
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| Main Authors: | , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/21025 |
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| Institution: | Mahidol University |