Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells

• Main Authors: Waraporn Chan-on, Nguyen Thi Bich Huyen, Napat Songtawee, Wilasinee Suwanjang, Supaluk Prachayasittikul, Virapong Prachayasittikul
• Other Authors: Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology
• Format: Article
• Language: English
• Published: 2015
• Subjects: FoxM1; cholangiocarcinoma; 8-hydroxyquinoline derivatives; clioquinol; nitroxoline; migration; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/2118
• Institution: Mahidol University

Purpose: Fork head box M1 (FoxM1) is an oncogenic transcription factor frequently elevated in numerous cancers, including cholangiocarcinoma (CCA). A growing body of evidence documents its diverse functions contributing to tumorigenesis and cancer progression. As such, discovery of agents that can t...