Epidemiological and Molecular Characterization of Dengue Virus Circulating in Bhutan, 2013-2014

Epidemiological and Molecular Characterization of Dengue Virus Circulating in Bhutan, 2013-2014

Dengue is one of the most significant public health problems in tropical and subtropical countries, and is increasingly being detected in traditionally non-endemic areas. In Bhutan, dengue virus (DENV) has only recently been detected and limited information is available. In this study, we analyzed t...

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Main Authors: Sangay Zangmo, Chonticha Klungthong, Piyawan Chinnawirotpisan, Srisurang Tantimavanich, Nathamon Kosoltanapiwat, Butsaya Thaisomboonsuk, Kelzang Phuntsho, Sonam Wangchuk, In-Kyu Yoon, Stefan Fernandez
Other Authors: Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology
Format: Article
Language:English
Published: 2015
Subjects:
Open Access article
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/2124
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Institution: Mahidol University
Language: English
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Summary:Dengue is one of the most significant public health problems in tropical and subtropical countries, and is increasingly being detected in traditionally non-endemic areas. In Bhutan, dengue virus (DENV) has only recently been detected and limited information is available. In this study, we analyzed the epidemiological and molecular characteristics of DENV in two southern districts in Bhutan from 2013–2014. During this period, 379 patients were clinically diagnosed with suspected dengue, of whom 119 (31.4%) were positive for DENV infection by NS1 ELISA and/or nested RT-PCR. DENV serotypes 1, 2 and 3 were detected with DENV-1 being predominant. Phylogenetic analysis of DENV-1 using envelope gene demonstrated genotype V, closely related to strains from northern India.

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