Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection

• Main Authors: Jun Ohashi, Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Gary Brittenham, Sornchai Looareesuwan, Andrew G. Clark, Katsushi Tokunaga
• Other Authors: University of Tokyo
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/21249
• Institution: Mahidol University

The hemoglobin E variant (HbE;β26Glu→Lys) is concentrated in parts of Southeast Asia where malaria is endemic, and HbE carrier status has been shown to confer some protection against Plasmodium falciparum malaria. To examine the effect of natural selection on the pattern of linkage disequilibrium (L...