Identification of residues in the dengue virus type 2 NS2B cofactor that are critical for NS3 protease activation

• Main Authors: Pornwaratt Niyomrattanakit, Pakorn Winoyanuwattikun, Santad Chanprapaph, Chanan Angsuthanasombat, Sakol Panyim, Gerd Katzenmeier
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/21334

Proteolytic processing of the dengue virus polyprotein is mediated by host cell proteases and the virus-encoded NS2B-NS3 two-component protease. The NS3 protease represents an attractive target for the development of antiviral inhibitors. The three-dimensional structure of the NS3 protease domain ha...