Hemozoin differentially regulates proinflammatory cytokine production in human immunodeficiency virus-seropositive and -seronegative women with placental malaria

• Main Authors: Julie M. Moore, Sujittra Chaisavaneeyakorn, Douglas J. Perkins, Caroline Othoro, Juliana Otieno, Bernard L. Nahlen, Ya Ping Shi, Venkatachalam Udhayakumar
• Other Authors: The University of Georgia
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/21342
• Institution: Mahidol University

Pregnant women are at an increased risk for malarial infection. Plasmodinm falciparum accumulates in the placenta and is associated with dysregulated immune function and poor birth outcomes. Malarial pigment (hemozoin) also accumulates in the placenta and may modulate local immune function. In this...