In vitro evaluation of intestinal absorption of desmopressin using drug-delivery systems based on superporous hydrogels

• Main Authors: Assadang Polnok, J. Coos Verhoef, Gerrit Borchard, Narong Sarisuta, Hans E. Junginger
• Other Authors: Leiden University
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/21809
• Institution: Mahidol University

The aim of this study was to investigate and modify the potential of drug-delivery systems based on superporous hydrogel (SPH) for improving the intestinal transport of the peptide drug desmopressin in vitro. The swelling properties and mechanical strength of SPHs were studied. The release profile o...