Depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer

This is a report of results from a case‐control study of the relationship of the long‐acting progestational contraceptive, depot‐medroxyprogesterone acetate (DMPA) to risk of endometrial carcinoma. Prior use of DMPA and information on known and suspected risk factors for endometrial cancer were asce...

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Main Authors: Suporn Silpisornkosol, Tieng Pardthaisong, Virote Sahapong, Choti Theetranont, Banpot Boosiri, Supawat Chutivongse, Pramuan Virutamasen, Chansuda Wongsrchanalai, Sermsri Sindhvananda, Suporn Koetsawang, Daungdao Rachawat, Amom Koetsawang, F. A. Langley, David B. Thomas Study Coordinator, Roberta M. Ray, Elizabeth A. Noonan, Janet L. Stanford, Karin A. Rosenblatt, Susan Holck, Timothy M.M. Farley, David B. Thomas
Other Authors: Chiang Mai University
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/22014
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spelling th-mahidol.220142018-08-10T15:36:15Z Depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer Suporn Silpisornkosol Tieng Pardthaisong Virote Sahapong Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrchanalai Sermsri Sindhvananda Suporn Koetsawang Daungdao Rachawat Amom Koetsawang F. A. Langley David B. Thomas Study Coordinator Roberta M. Ray Elizabeth A. Noonan Janet L. Stanford Karin A. Rosenblatt Susan Holck Timothy M.M. Farley David B. Thomas Roberta M. Ray Chiang Mai University Chulalongkorn University Mahidol University St Mary's Hospital London Fred Hutchinson Cancer Research Center Organisation Mondiale de la Sante Biochemistry, Genetics and Molecular Biology Medicine This is a report of results from a case‐control study of the relationship of the long‐acting progestational contraceptive, depot‐medroxyprogesterone acetate (DMPA) to risk of endometrial carcinoma. Prior use of DMPA and information on known and suspected risk factors for endometrial cancer were ascertained in personal interviews with 122 women with histologically confirmed disease and 939 controls selected from 2 hospitals in Bangkok and 1 in Chiang Mai, Thailand. Based on 3 exposed cases and 84 exposed controls, the relative risk of endometrial cancer was estimated to be 0.21 (95% confidence interval = 0.06,0.79) in women who had ever used DMPA (but who had not first used DMPA in the year prior to diagnosis). All 3 exposed cases had also received estrogens pre‐menopausally. Exposure to such estrogens enhanced risk of endometrial cancer and reduced the apparent protective effect of DMPA. Although based on small numbers of exposed women, the protective effect of DMPA appeared to last for at least 8 years after cessation of use. The reduction in risk of endometrial cancer is at least as great for DMPA as for combined oral contraceptives. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company 2018-08-10T08:31:06Z 2018-08-10T08:31:06Z 1991-01-01 Article International Journal of Cancer. Vol.49, No.2 (1991), 186-190 10.1002/ijc.2910490207 10970215 00207136 2-s2.0-0025826644 https://repository.li.mahidol.ac.th/handle/123456789/22014 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025826644&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Suporn Silpisornkosol
Tieng Pardthaisong
Virote Sahapong
Choti Theetranont
Banpot Boosiri
Supawat Chutivongse
Pramuan Virutamasen
Chansuda Wongsrchanalai
Sermsri Sindhvananda
Suporn Koetsawang
Daungdao Rachawat
Amom Koetsawang
F. A. Langley
David B. Thomas Study Coordinator
Roberta M. Ray
Elizabeth A. Noonan
Janet L. Stanford
Karin A. Rosenblatt
Susan Holck
Timothy M.M. Farley
David B. Thomas
Roberta M. Ray
Depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer
description This is a report of results from a case‐control study of the relationship of the long‐acting progestational contraceptive, depot‐medroxyprogesterone acetate (DMPA) to risk of endometrial carcinoma. Prior use of DMPA and information on known and suspected risk factors for endometrial cancer were ascertained in personal interviews with 122 women with histologically confirmed disease and 939 controls selected from 2 hospitals in Bangkok and 1 in Chiang Mai, Thailand. Based on 3 exposed cases and 84 exposed controls, the relative risk of endometrial cancer was estimated to be 0.21 (95% confidence interval = 0.06,0.79) in women who had ever used DMPA (but who had not first used DMPA in the year prior to diagnosis). All 3 exposed cases had also received estrogens pre‐menopausally. Exposure to such estrogens enhanced risk of endometrial cancer and reduced the apparent protective effect of DMPA. Although based on small numbers of exposed women, the protective effect of DMPA appeared to last for at least 8 years after cessation of use. The reduction in risk of endometrial cancer is at least as great for DMPA as for combined oral contraceptives. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company
author2 Chiang Mai University
author_facet Chiang Mai University
Suporn Silpisornkosol
Tieng Pardthaisong
Virote Sahapong
Choti Theetranont
Banpot Boosiri
Supawat Chutivongse
Pramuan Virutamasen
Chansuda Wongsrchanalai
Sermsri Sindhvananda
Suporn Koetsawang
Daungdao Rachawat
Amom Koetsawang
F. A. Langley
David B. Thomas Study Coordinator
Roberta M. Ray
Elizabeth A. Noonan
Janet L. Stanford
Karin A. Rosenblatt
Susan Holck
Timothy M.M. Farley
David B. Thomas
Roberta M. Ray
format Article
author Suporn Silpisornkosol
Tieng Pardthaisong
Virote Sahapong
Choti Theetranont
Banpot Boosiri
Supawat Chutivongse
Pramuan Virutamasen
Chansuda Wongsrchanalai
Sermsri Sindhvananda
Suporn Koetsawang
Daungdao Rachawat
Amom Koetsawang
F. A. Langley
David B. Thomas Study Coordinator
Roberta M. Ray
Elizabeth A. Noonan
Janet L. Stanford
Karin A. Rosenblatt
Susan Holck
Timothy M.M. Farley
David B. Thomas
Roberta M. Ray
author_sort Suporn Silpisornkosol
title Depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer
title_short Depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer
title_full Depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer
title_fullStr Depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer
title_full_unstemmed Depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer
title_sort depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/22014
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