Nasopharyngeal carcinoma: Results of treatment by radiotherapy vs chemotherapy plus radiotherapy

To determine the efficacy of neoadjuvant chemotherapy over radiotherapy alone in locally advanced nasopharyngeal carcinoma, a prospective non-randomized study was performed from 1 January 1982 to 31 Decemberm 1985 at Ramathibodi Hospital, Thailand. There were 69 new cases who completed treatment and...

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Main Authors: P. Kraiphibul, P. Clongsusuek, V. Ratanatharathorn, V. Atichartakarn, B. Kulapaditharom, W. Isarangkul
Other Authors: Mahidol University
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Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/22098
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spelling th-mahidol.220982018-08-10T15:32:56Z Nasopharyngeal carcinoma: Results of treatment by radiotherapy vs chemotherapy plus radiotherapy P. Kraiphibul P. Clongsusuek V. Ratanatharathorn V. Atichartakarn B. Kulapaditharom W. Isarangkul Mahidol University Medicine To determine the efficacy of neoadjuvant chemotherapy over radiotherapy alone in locally advanced nasopharyngeal carcinoma, a prospective non-randomized study was performed from 1 January 1982 to 31 Decemberm 1985 at Ramathibodi Hospital, Thailand. There were 69 new cases who completed treatment and were followed up at least once. Thirty-three cases were treated by radical radiotherapy (RT) alone and 36 cases by chemotherapy (CT) + RT. CT were by the combination of cis-diamminedichloroplatinum II and 5 fluorouracil. Of 32 cases, 2 courses of CT were given before RT and 1 after. The other 4 received 3 courses prior to RT. For both groups, RT technique and dosage were similar. Follow-up time of both groups ranged from 6-104 months (X̄ 50.3, median 50) and 8-100 months (X̄ 52.2, median 54.5), and total failures were 18/33 and 13/36, respectively, wiht no statistical difference (p ~ 0.05). Estimated actual survival and disease free survival from Kaplan-Meier curves at 3 years were about 75 per cent vs 75 per cent and 65 per cent vs 65 per cent, respectively, with no statistical differences (Log-Rank test). Therefore, we concluded that induction chemotherapy had some benefit but no statistical significance over RT alone. However, the role of maintenance chemotherapy is now being studied. 2018-08-10T08:32:56Z 2018-08-10T08:32:56Z 1991-12-01 Article Journal of the Medical Association of Thailand. Vol.74, No.9 (1991), 391-396 01252208 2-s2.0-0026315711 https://repository.li.mahidol.ac.th/handle/123456789/22098 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0026315711&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
P. Kraiphibul
P. Clongsusuek
V. Ratanatharathorn
V. Atichartakarn
B. Kulapaditharom
W. Isarangkul
Nasopharyngeal carcinoma: Results of treatment by radiotherapy vs chemotherapy plus radiotherapy
description To determine the efficacy of neoadjuvant chemotherapy over radiotherapy alone in locally advanced nasopharyngeal carcinoma, a prospective non-randomized study was performed from 1 January 1982 to 31 Decemberm 1985 at Ramathibodi Hospital, Thailand. There were 69 new cases who completed treatment and were followed up at least once. Thirty-three cases were treated by radical radiotherapy (RT) alone and 36 cases by chemotherapy (CT) + RT. CT were by the combination of cis-diamminedichloroplatinum II and 5 fluorouracil. Of 32 cases, 2 courses of CT were given before RT and 1 after. The other 4 received 3 courses prior to RT. For both groups, RT technique and dosage were similar. Follow-up time of both groups ranged from 6-104 months (X̄ 50.3, median 50) and 8-100 months (X̄ 52.2, median 54.5), and total failures were 18/33 and 13/36, respectively, wiht no statistical difference (p ~ 0.05). Estimated actual survival and disease free survival from Kaplan-Meier curves at 3 years were about 75 per cent vs 75 per cent and 65 per cent vs 65 per cent, respectively, with no statistical differences (Log-Rank test). Therefore, we concluded that induction chemotherapy had some benefit but no statistical significance over RT alone. However, the role of maintenance chemotherapy is now being studied.
author2 Mahidol University
author_facet Mahidol University
P. Kraiphibul
P. Clongsusuek
V. Ratanatharathorn
V. Atichartakarn
B. Kulapaditharom
W. Isarangkul
format Article
author P. Kraiphibul
P. Clongsusuek
V. Ratanatharathorn
V. Atichartakarn
B. Kulapaditharom
W. Isarangkul
author_sort P. Kraiphibul
title Nasopharyngeal carcinoma: Results of treatment by radiotherapy vs chemotherapy plus radiotherapy
title_short Nasopharyngeal carcinoma: Results of treatment by radiotherapy vs chemotherapy plus radiotherapy
title_full Nasopharyngeal carcinoma: Results of treatment by radiotherapy vs chemotherapy plus radiotherapy
title_fullStr Nasopharyngeal carcinoma: Results of treatment by radiotherapy vs chemotherapy plus radiotherapy
title_full_unstemmed Nasopharyngeal carcinoma: Results of treatment by radiotherapy vs chemotherapy plus radiotherapy
title_sort nasopharyngeal carcinoma: results of treatment by radiotherapy vs chemotherapy plus radiotherapy
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/22098
_version_ 1763491686604865536