Aberrant splicing caused by the insertion of the B2 sequence into an intron of the complement C4 gene is the basis for low C4 production in H-2k mice
The serum level of the fourth component of complement (C4) in mice bearing the H-2k haplotype is only 1/10 to 1/20 of that of non-H-2k mice. We have analyzed C4 cDNA clones from B10.BR(H-2k) mouse liver and found aberrant C4 cDNA which contained a 200-base pair (bp) insertion between the exon 13 and...
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Main Authors: | Sa Nga Pattanakitsakul, Jia Hua Zheng, Shunnosuke Natsuume-Sakai, Morinobu Takahashi, Masaru Nonaka |
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Other Authors: | Mahidol University |
Format: | Article |
Published: |
2018
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Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/22257 |
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Institution: | Mahidol University |
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