The effects of hemoglobin genotype and ABO blood group on the formation of rosettes by Plasmodium falciparum-infected red blood cells
The mechanisms by which the hemoglobin genotype AS protect against severe malaria are not fully understood. We have investigated the possibility that protection might be achieved through an inability of red blood cells (RBC) with the AS genotype to form rosettes with RBC infected by Plasmodium falci...
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th-mahidol.225872018-08-10T15:59:18Z The effects of hemoglobin genotype and ABO blood group on the formation of rosettes by Plasmodium falciparum-infected red blood cells R. Udomsangpetch J. Todd J. Carlson B. M. Greenwood Mahidol University Immunology and Microbiology Medicine The mechanisms by which the hemoglobin genotype AS protect against severe malaria are not fully understood. We have investigated the possibility that protection might be achieved through an inability of red blood cells (RBC) with the AS genotype to form rosettes with RBC infected by Plasmodium falciparum. No evidence was obtained to support this hypothesis because RBC with the AS genotype formed rosettes with wild isolates of P. falciparum as readily as RBC with the AA genotype. However, the previous finding that parasitized RBC form rosettes more readily with RBC belonging to group A or B than with RBC belonging to group O was confirmed even in fresh clinical isolates. 2018-08-10T08:55:30Z 2018-08-10T08:55:30Z 1993-01-01 Article American Journal of Tropical Medicine and Hygiene. Vol.48, No.2 (1993), 149-153 10.4269/ajtmh.1993.48.149 00029637 2-s2.0-0027509663 https://repository.li.mahidol.ac.th/handle/123456789/22587 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0027509663&origin=inward |
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Immunology and Microbiology Medicine R. Udomsangpetch J. Todd J. Carlson B. M. Greenwood The effects of hemoglobin genotype and ABO blood group on the formation of rosettes by Plasmodium falciparum-infected red blood cells |
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The mechanisms by which the hemoglobin genotype AS protect against severe malaria are not fully understood. We have investigated the possibility that protection might be achieved through an inability of red blood cells (RBC) with the AS genotype to form rosettes with RBC infected by Plasmodium falciparum. No evidence was obtained to support this hypothesis because RBC with the AS genotype formed rosettes with wild isolates of P. falciparum as readily as RBC with the AA genotype. However, the previous finding that parasitized RBC form rosettes more readily with RBC belonging to group A or B than with RBC belonging to group O was confirmed even in fresh clinical isolates. |
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Mahidol University |
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Mahidol University R. Udomsangpetch J. Todd J. Carlson B. M. Greenwood |
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Article |
author |
R. Udomsangpetch J. Todd J. Carlson B. M. Greenwood |
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R. Udomsangpetch |
title |
The effects of hemoglobin genotype and ABO blood group on the formation of rosettes by Plasmodium falciparum-infected red blood cells |
title_short |
The effects of hemoglobin genotype and ABO blood group on the formation of rosettes by Plasmodium falciparum-infected red blood cells |
title_full |
The effects of hemoglobin genotype and ABO blood group on the formation of rosettes by Plasmodium falciparum-infected red blood cells |
title_fullStr |
The effects of hemoglobin genotype and ABO blood group on the formation of rosettes by Plasmodium falciparum-infected red blood cells |
title_full_unstemmed |
The effects of hemoglobin genotype and ABO blood group on the formation of rosettes by Plasmodium falciparum-infected red blood cells |
title_sort |
effects of hemoglobin genotype and abo blood group on the formation of rosettes by plasmodium falciparum-infected red blood cells |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/22587 |
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1763495942413090816 |