Effects of 17β-estradiol on intracellular calcium changes and neuronal survival after mechanical strain injury in neuronal-glial cultures

• Main Authors: Saitida Lapanantasin, Sukumal Chongthammakun, Candace L. Floyd, Robert F. Berman
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Neuroscience; Nursing; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/22968

The neuroprotective effects of 17β-estradiol (E2) were investigated using an in vitro model of traumatic brain injury in which cortical neuronal cultures were subjected to mechanical strain-injury. The rise in intracellular calcium ([Ca2+]i) following neuronal injury was reduced by addition of 10 or...