Combined antioxidant (β-carotene, α-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model

• Main Authors: Yuri Kim, Nalinee Chongviriyaphan, Chun Liu, Robert M. Russell, Xiang Dong Wang
• Other Authors: Jean Mayer USDA Human Nutrition Research Center on Aging
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23013
• Institution: Mahidol University

Interactions among β-carotene (BC), α-tocopherol (AT) and ascorbic acid (AA) led to the hypothesis that using a combination of these antioxidants could be more beneficial than using a single antioxidant alone, particularly against smoke-related lung cancer. In this investigation, we have conducted a...