Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry

Vacuum is not the limit: direct analysis in real time (DART), a new MS ionization method, allows probing of pharmaceuticals under atmospheric pressure, thus bypassing lengthy sample preparation steps and enhancing throughput. DART allows rapid screening of solid drugs at almost constant temperature...

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Main Authors:	Facundo M. Fernández, Robert B. Cody, Michael D. Green, Christina Y. Hampton, Rose McGready, Sivong Sengaloundeth, Nicholas J. White, Paul N. Newton
Other Authors:	Georgia Institute of Technology
Format:	Article
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/23019
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Institution:	Mahidol University

id	th-mahidol.23019
record_format	dspace
spelling	th-mahidol.230192018-08-20T14:24:33Z Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry Facundo M. Fernández Robert B. Cody Michael D. Green Christina Y. Hampton Rose McGready Sivong Sengaloundeth Nicholas J. White Paul N. Newton Georgia Institute of Technology JEOL USA Inc. National Center for Infectious Diseases Shoklo Malaria Research Unit Ministry of Health Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration University of Oxford Mahidol University Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Vacuum is not the limit: direct analysis in real time (DART), a new MS ionization method, allows probing of pharmaceuticals under atmospheric pressure, thus bypassing lengthy sample preparation steps and enhancing throughput. DART allows rapid screening of solid drugs at almost constant temperature which decreases errors in mass measurement and improves the identification of potentially harmful unknowns. This is important for identifying counterfeit drugs (fake hologram shown). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA. 2018-08-20T06:51:06Z 2018-08-20T06:51:06Z 2006-07-01 Article ChemMedChem. Vol.1, No.7 (2006), 702-705 10.1002/cmdc.200600041 18607187 18607179 2-s2.0-33745587210 https://repository.li.mahidol.ac.th/handle/123456789/23019 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745587210&origin=inward
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Facundo M. Fernández Robert B. Cody Michael D. Green Christina Y. Hampton Rose McGready Sivong Sengaloundeth Nicholas J. White Paul N. Newton Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry
description	Vacuum is not the limit: direct analysis in real time (DART), a new MS ionization method, allows probing of pharmaceuticals under atmospheric pressure, thus bypassing lengthy sample preparation steps and enhancing throughput. DART allows rapid screening of solid drugs at almost constant temperature which decreases errors in mass measurement and improves the identification of potentially harmful unknowns. This is important for identifying counterfeit drugs (fake hologram shown). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
author2	Georgia Institute of Technology
author_facet	Georgia Institute of Technology Facundo M. Fernández Robert B. Cody Michael D. Green Christina Y. Hampton Rose McGready Sivong Sengaloundeth Nicholas J. White Paul N. Newton
format	Article
author	Facundo M. Fernández Robert B. Cody Michael D. Green Christina Y. Hampton Rose McGready Sivong Sengaloundeth Nicholas J. White Paul N. Newton
author_sort	Facundo M. Fernández
title	Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry
title_short	Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry
title_full	Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry
title_fullStr	Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry
title_full_unstemmed	Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry
title_sort	characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry
publishDate	2018
url	https://repository.li.mahidol.ac.th/handle/123456789/23019
_version_	1763489878192947200

Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry

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