Extra-tumoral breast tissue in breast cancer patients: Variations with steroid contraceptive use
The association between oral contraceptive (OC) use and benign breast changes in extra-tumoral breast tissue was studied histologically in 1,503 breast cancer patients from The WHO Collaborative Study of Neoplasia and Steroid Contraceptives. The occurrence of ductal hyperplasia, ductal atypia, scler...
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th-mahidol.230372018-08-20T14:16:50Z Extra-tumoral breast tissue in breast cancer patients: Variations with steroid contraceptive use Tone B.Aaman Vamre Helge Stalsberg David B. Thomas G. Berry R. Maclennan R. Shearman T. Jelihovsky J. Cooper Booth R. Molina L. Martinez O. Salas A. Dabacens Cheng Zhiheng Tao Yun Hu Yong Wei A. Cuadros N. Aristizabal K. Ebeling P. Nishan D. Kunde B. Modan E. Ron E. Alfandary J. G. Mati P. Kenya A. Kungu D. Gatei H. Rodriguez Cuevas S. Benavides Salazar A. Palet P. Ontiveros R. A. Apelo J. R. De La Cruz J. Baens B. Javier Suporn Silpisornkosol Tieng Pardthaisong Nimit Martin Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Prasarn Jimakorn Supom Koetsawang Daungdao Rachawat Nivat Chantarakul R. M. Ray E. A. Noonan S. Holck UiT Norges Arktiske Universitet Fred Hutchinson Cancer Research Center The University of Sydney Hospital Jose Joaquin Aguirre Hospital del Salvador Shanghai Institute of Planned Parenthood Research Hospital Universitario Akademie der Wissenschaften der DDR Chaim Sheba Medical Center Israel University of Nairobi Hospital General de Mexico University of the Philippines Manila Chiang Mai University Chulalongkorn University Mahidol University Organisation Mondiale de la Sante Development and Research Training in Human Reproduction Biochemistry, Genetics and Molecular Biology Medicine The association between oral contraceptive (OC) use and benign breast changes in extra-tumoral breast tissue was studied histologically in 1,503 breast cancer patients from The WHO Collaborative Study of Neoplasia and Steroid Contraceptives. The occurrence of ductal hyperplasia, ductal atypia, sclerosing adenosis, cysts, apocrine metaplasia, apocrine hyperplasia, apocrine atypia, adenosis, lobular atypia, duct ectasia, calcifications, inflammatory reaction, lactational metaplasia and a high epithelial-stromal ratio was graded semi-quantitatively. Prevalence odds ratio (POR) for each histologic variable was calculated by logistic regression analyses. Patients who had ever used OC had lower occurrence of ductal hyperplasia than never users (POR 0.72 (95% CI 0.52-0.99)). Current use and more than 8 years of use was also associated with a lower prevalence of ductal hyperplasia (POR 0.40 (0.20-0.81) and POR 0.33 (0.17-0.64), respectively). Age > 35 years at first use was associated with increased prevalence of ductal carcinoma in situ (POR 2.15 (1.05-4.40)), but not of atypical ductal hyperplasia. Our results show that the effects of OC use on ductal hyperplasia in non-neoplastic breast tissue of breast cancer patients are similar to what others have found in patients with benign breast disease only. The increased prevalence of extra-tumoral ductal carcinoma in situ in breast cancer patients who started OC use at high age may possibly be explained by a longer preinvasive phase in these patients. © 2005 Wiley-Liss, Inc. 2018-08-20T06:51:35Z 2018-08-20T06:51:35Z 2006-06-01 Article International Journal of Cancer. Vol.118, No.11 (2006), 2827-2831 10.1002/ijc.21697 10970215 00207136 2-s2.0-33646367649 https://repository.li.mahidol.ac.th/handle/123456789/23037 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33646367649&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Tone B.Aaman Vamre Helge Stalsberg David B. Thomas G. Berry R. Maclennan R. Shearman T. Jelihovsky J. Cooper Booth R. Molina L. Martinez O. Salas A. Dabacens Cheng Zhiheng Tao Yun Hu Yong Wei A. Cuadros N. Aristizabal K. Ebeling P. Nishan D. Kunde B. Modan E. Ron E. Alfandary J. G. Mati P. Kenya A. Kungu D. Gatei H. Rodriguez Cuevas S. Benavides Salazar A. Palet P. Ontiveros R. A. Apelo J. R. De La Cruz J. Baens B. Javier Suporn Silpisornkosol Tieng Pardthaisong Nimit Martin Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Prasarn Jimakorn Supom Koetsawang Daungdao Rachawat Nivat Chantarakul R. M. Ray E. A. Noonan S. Holck Extra-tumoral breast tissue in breast cancer patients: Variations with steroid contraceptive use |
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The association between oral contraceptive (OC) use and benign breast changes in extra-tumoral breast tissue was studied histologically in 1,503 breast cancer patients from The WHO Collaborative Study of Neoplasia and Steroid Contraceptives. The occurrence of ductal hyperplasia, ductal atypia, sclerosing adenosis, cysts, apocrine metaplasia, apocrine hyperplasia, apocrine atypia, adenosis, lobular atypia, duct ectasia, calcifications, inflammatory reaction, lactational metaplasia and a high epithelial-stromal ratio was graded semi-quantitatively. Prevalence odds ratio (POR) for each histologic variable was calculated by logistic regression analyses. Patients who had ever used OC had lower occurrence of ductal hyperplasia than never users (POR 0.72 (95% CI 0.52-0.99)). Current use and more than 8 years of use was also associated with a lower prevalence of ductal hyperplasia (POR 0.40 (0.20-0.81) and POR 0.33 (0.17-0.64), respectively). Age > 35 years at first use was associated with increased prevalence of ductal carcinoma in situ (POR 2.15 (1.05-4.40)), but not of atypical ductal hyperplasia. Our results show that the effects of OC use on ductal hyperplasia in non-neoplastic breast tissue of breast cancer patients are similar to what others have found in patients with benign breast disease only. The increased prevalence of extra-tumoral ductal carcinoma in situ in breast cancer patients who started OC use at high age may possibly be explained by a longer preinvasive phase in these patients. © 2005 Wiley-Liss, Inc. |
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UiT Norges Arktiske Universitet |
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UiT Norges Arktiske Universitet Tone B.Aaman Vamre Helge Stalsberg David B. Thomas G. Berry R. Maclennan R. Shearman T. Jelihovsky J. Cooper Booth R. Molina L. Martinez O. Salas A. Dabacens Cheng Zhiheng Tao Yun Hu Yong Wei A. Cuadros N. Aristizabal K. Ebeling P. Nishan D. Kunde B. Modan E. Ron E. Alfandary J. G. Mati P. Kenya A. Kungu D. Gatei H. Rodriguez Cuevas S. Benavides Salazar A. Palet P. Ontiveros R. A. Apelo J. R. De La Cruz J. Baens B. Javier Suporn Silpisornkosol Tieng Pardthaisong Nimit Martin Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Prasarn Jimakorn Supom Koetsawang Daungdao Rachawat Nivat Chantarakul R. M. Ray E. A. Noonan S. Holck |
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Article |
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Tone B.Aaman Vamre Helge Stalsberg David B. Thomas G. Berry R. Maclennan R. Shearman T. Jelihovsky J. Cooper Booth R. Molina L. Martinez O. Salas A. Dabacens Cheng Zhiheng Tao Yun Hu Yong Wei A. Cuadros N. Aristizabal K. Ebeling P. Nishan D. Kunde B. Modan E. Ron E. Alfandary J. G. Mati P. Kenya A. Kungu D. Gatei H. Rodriguez Cuevas S. Benavides Salazar A. Palet P. Ontiveros R. A. Apelo J. R. De La Cruz J. Baens B. Javier Suporn Silpisornkosol Tieng Pardthaisong Nimit Martin Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Prasarn Jimakorn Supom Koetsawang Daungdao Rachawat Nivat Chantarakul R. M. Ray E. A. Noonan S. Holck |
author_sort |
Tone B.Aaman Vamre |
title |
Extra-tumoral breast tissue in breast cancer patients: Variations with steroid contraceptive use |
title_short |
Extra-tumoral breast tissue in breast cancer patients: Variations with steroid contraceptive use |
title_full |
Extra-tumoral breast tissue in breast cancer patients: Variations with steroid contraceptive use |
title_fullStr |
Extra-tumoral breast tissue in breast cancer patients: Variations with steroid contraceptive use |
title_full_unstemmed |
Extra-tumoral breast tissue in breast cancer patients: Variations with steroid contraceptive use |
title_sort |
extra-tumoral breast tissue in breast cancer patients: variations with steroid contraceptive use |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/23037 |
_version_ |
1763487524066426880 |