A direct catalytic asymmetric Mannich-type reaction via a dinuclear zinc catalyst: Synthesis of either anti- or syn-α-hydroxy-β-amino ketones

• Main Authors: Barry M. Trost, Jaray Jaratjaroonphong, Vichai Reutrakul
• Other Authors: Stanford University
• Format: Article
• Published: 2018
• Subjects: Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23177
• Institution: Mahidol University

The use of imines bearing a hydrolyzable nitrogen substituent in direct asymmetric Mannich reactions with α-hydroxyketones is developed. Previous work focused on the use of N-arylimines or nonenolizable imines, and the latter with only methoxy-substituted α-hydroxyacetophenones. Using a dinuclear ca...