Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w
Several genes of Plasmodium falciparum are positively selected due to the pressure from the host immune system. This is a pattern completely opposite to that found in most housekeeping genes, which have few synonymous mutations. The discrepancy is an important topic in Plasmodium biology. We searche...
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th-mahidol.233022018-08-20T14:00:28Z Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w Thanat Chookajorn Daniel L. Hartl Harvard University Mahidol University Immunology and Microbiology Several genes of Plasmodium falciparum are positively selected due to the pressure from the host immune system. This is a pattern completely opposite to that found in most housekeeping genes, which have few synonymous mutations. The discrepancy is an important topic in Plasmodium biology. We searched for unique polymorphism patterns in P. falciparum and identified a repetitive Stuttering motif in PFI1780w which was recently grouped as a gene in the PHIST family. The repeat has a position-specific polymorphism pattern in the otherwise highly conserved gene. Its mutations are limited to only one small region, and they are not consistent with replication slippage or gene conversion commonly found in low complexity regions. The repeat variation was analyzed in different strains of P. falciparum. The PFI1780w Stuttering motif can be a model to study gene diversification and used as a tool for strain typing. © 2006 Elsevier Inc. All rights reserved. 2018-08-20T07:00:28Z 2018-08-20T07:00:28Z 2006-10-01 Article Experimental Parasitology. Vol.114, No.2 (2006), 126-128 10.1016/j.exppara.2006.02.019 10902449 00144894 2-s2.0-33748521844 https://repository.li.mahidol.ac.th/handle/123456789/23302 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748521844&origin=inward |
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Immunology and Microbiology Thanat Chookajorn Daniel L. Hartl Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w |
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Several genes of Plasmodium falciparum are positively selected due to the pressure from the host immune system. This is a pattern completely opposite to that found in most housekeeping genes, which have few synonymous mutations. The discrepancy is an important topic in Plasmodium biology. We searched for unique polymorphism patterns in P. falciparum and identified a repetitive Stuttering motif in PFI1780w which was recently grouped as a gene in the PHIST family. The repeat has a position-specific polymorphism pattern in the otherwise highly conserved gene. Its mutations are limited to only one small region, and they are not consistent with replication slippage or gene conversion commonly found in low complexity regions. The repeat variation was analyzed in different strains of P. falciparum. The PFI1780w Stuttering motif can be a model to study gene diversification and used as a tool for strain typing. © 2006 Elsevier Inc. All rights reserved. |
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Harvard University |
author_facet |
Harvard University Thanat Chookajorn Daniel L. Hartl |
format |
Article |
author |
Thanat Chookajorn Daniel L. Hartl |
author_sort |
Thanat Chookajorn |
title |
Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w |
title_short |
Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w |
title_full |
Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w |
title_fullStr |
Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w |
title_full_unstemmed |
Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w |
title_sort |
position-specific polymorphism of plasmodium falciparum stuttering motif in a phistc pfi1780w |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/23302 |
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1763489971776258048 |