Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study

Purpose: To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease. Design: Retrospective, population-based, case-control study. Methods: setting: Large, regional health maintenance organization (Northern California Kaiser Permanente). study Population: 1,042,351 people...

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Main Authors: Tisha Prabriputaloong, Todd P. Margolis, Thomas M. Lietman, Ira G. Wong, Rookaya Mather, David C. Gritz
Other Authors: University of California, San Francisco
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Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/23524
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spelling th-mahidol.235242018-08-20T14:08:55Z Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study Tisha Prabriputaloong Todd P. Margolis Thomas M. Lietman Ira G. Wong Rookaya Mather David C. Gritz University of California, San Francisco Mahidol University Stanford University Western University Permanente Medical Group Medicine Purpose: To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease. Design: Retrospective, population-based, case-control study. Methods: setting: Large, regional health maintenance organization (Northern California Kaiser Permanente). study Population: 1,042,351 people over a one-year period. observation Procedures: Electronic database search for HSV ocular disease and subsequent chart review determined study eligibility. Two age-matched control groups (one population-based and one clinic-based) were randomly chosen. Medical record review determined the presence of atopy. Severe atopic disease was defined by diagnostic code or illness requiring an emergency room visit, hospitalization, or treatment with a systemic corticosteroid. main Outcome Measures: Presence of HSV eye disease, presence of atopy, and characterization of atopy severity. Results: HSV eye disease was found in 172 patients. HSV cases had a greater prevalence of atopy (34%, 58/172) than the clinic-based (25%, 43/172) or the population-based controls (21%, 36/172, odds ratio (OR) 1.5, 95% confidence interval (CI) 0.9 to 2.6 and OR 1.9, 95%, CI 1.1 to 3.3, respectively). The association of HSV ocular disease with severe atopy was even greater, with a history of severe atopic disease in 13% (22/172) of patients with HSV ocular disease as compared with 6% (11/172) of patients in the clinic control group and 3% (5/172) of patients in the population control group (OR 2.0, 95% CI 0.7 to 5.9 and OR 4.8, 95% CI 1.6 to 19.2, respectively). Conclusions: Patients with HSV ocular disease are more likely to have a history of atopic disease, especially severe atopic disease, than age-matched controls. © 2006 Elsevier Inc. All rights reserved. 2018-08-20T07:08:55Z 2018-08-20T07:08:55Z 2006-11-01 Article American Journal of Ophthalmology. Vol.142, No.5 (2006) 10.1016/j.ajo.2006.06.050 00029394 2-s2.0-33750049019 https://repository.li.mahidol.ac.th/handle/123456789/23524 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33750049019&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Tisha Prabriputaloong
Todd P. Margolis
Thomas M. Lietman
Ira G. Wong
Rookaya Mather
David C. Gritz
Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study
description Purpose: To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease. Design: Retrospective, population-based, case-control study. Methods: setting: Large, regional health maintenance organization (Northern California Kaiser Permanente). study Population: 1,042,351 people over a one-year period. observation Procedures: Electronic database search for HSV ocular disease and subsequent chart review determined study eligibility. Two age-matched control groups (one population-based and one clinic-based) were randomly chosen. Medical record review determined the presence of atopy. Severe atopic disease was defined by diagnostic code or illness requiring an emergency room visit, hospitalization, or treatment with a systemic corticosteroid. main Outcome Measures: Presence of HSV eye disease, presence of atopy, and characterization of atopy severity. Results: HSV eye disease was found in 172 patients. HSV cases had a greater prevalence of atopy (34%, 58/172) than the clinic-based (25%, 43/172) or the population-based controls (21%, 36/172, odds ratio (OR) 1.5, 95% confidence interval (CI) 0.9 to 2.6 and OR 1.9, 95%, CI 1.1 to 3.3, respectively). The association of HSV ocular disease with severe atopy was even greater, with a history of severe atopic disease in 13% (22/172) of patients with HSV ocular disease as compared with 6% (11/172) of patients in the clinic control group and 3% (5/172) of patients in the population control group (OR 2.0, 95% CI 0.7 to 5.9 and OR 4.8, 95% CI 1.6 to 19.2, respectively). Conclusions: Patients with HSV ocular disease are more likely to have a history of atopic disease, especially severe atopic disease, than age-matched controls. © 2006 Elsevier Inc. All rights reserved.
author2 University of California, San Francisco
author_facet University of California, San Francisco
Tisha Prabriputaloong
Todd P. Margolis
Thomas M. Lietman
Ira G. Wong
Rookaya Mather
David C. Gritz
format Article
author Tisha Prabriputaloong
Todd P. Margolis
Thomas M. Lietman
Ira G. Wong
Rookaya Mather
David C. Gritz
author_sort Tisha Prabriputaloong
title Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study
title_short Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study
title_full Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study
title_fullStr Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study
title_full_unstemmed Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study
title_sort atopic disease and herpes simplex eye disease: a population-based case-control study
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/23524
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