Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study
Purpose: To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease. Design: Retrospective, population-based, case-control study. Methods: setting: Large, regional health maintenance organization (Northern California Kaiser Permanente). study Population: 1,042,351 people...
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th-mahidol.235242018-08-20T14:08:55Z Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study Tisha Prabriputaloong Todd P. Margolis Thomas M. Lietman Ira G. Wong Rookaya Mather David C. Gritz University of California, San Francisco Mahidol University Stanford University Western University Permanente Medical Group Medicine Purpose: To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease. Design: Retrospective, population-based, case-control study. Methods: setting: Large, regional health maintenance organization (Northern California Kaiser Permanente). study Population: 1,042,351 people over a one-year period. observation Procedures: Electronic database search for HSV ocular disease and subsequent chart review determined study eligibility. Two age-matched control groups (one population-based and one clinic-based) were randomly chosen. Medical record review determined the presence of atopy. Severe atopic disease was defined by diagnostic code or illness requiring an emergency room visit, hospitalization, or treatment with a systemic corticosteroid. main Outcome Measures: Presence of HSV eye disease, presence of atopy, and characterization of atopy severity. Results: HSV eye disease was found in 172 patients. HSV cases had a greater prevalence of atopy (34%, 58/172) than the clinic-based (25%, 43/172) or the population-based controls (21%, 36/172, odds ratio (OR) 1.5, 95% confidence interval (CI) 0.9 to 2.6 and OR 1.9, 95%, CI 1.1 to 3.3, respectively). The association of HSV ocular disease with severe atopy was even greater, with a history of severe atopic disease in 13% (22/172) of patients with HSV ocular disease as compared with 6% (11/172) of patients in the clinic control group and 3% (5/172) of patients in the population control group (OR 2.0, 95% CI 0.7 to 5.9 and OR 4.8, 95% CI 1.6 to 19.2, respectively). Conclusions: Patients with HSV ocular disease are more likely to have a history of atopic disease, especially severe atopic disease, than age-matched controls. © 2006 Elsevier Inc. All rights reserved. 2018-08-20T07:08:55Z 2018-08-20T07:08:55Z 2006-11-01 Article American Journal of Ophthalmology. Vol.142, No.5 (2006) 10.1016/j.ajo.2006.06.050 00029394 2-s2.0-33750049019 https://repository.li.mahidol.ac.th/handle/123456789/23524 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33750049019&origin=inward |
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Medicine Tisha Prabriputaloong Todd P. Margolis Thomas M. Lietman Ira G. Wong Rookaya Mather David C. Gritz Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study |
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Purpose: To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease. Design: Retrospective, population-based, case-control study. Methods: setting: Large, regional health maintenance organization (Northern California Kaiser Permanente). study Population: 1,042,351 people over a one-year period. observation Procedures: Electronic database search for HSV ocular disease and subsequent chart review determined study eligibility. Two age-matched control groups (one population-based and one clinic-based) were randomly chosen. Medical record review determined the presence of atopy. Severe atopic disease was defined by diagnostic code or illness requiring an emergency room visit, hospitalization, or treatment with a systemic corticosteroid. main Outcome Measures: Presence of HSV eye disease, presence of atopy, and characterization of atopy severity. Results: HSV eye disease was found in 172 patients. HSV cases had a greater prevalence of atopy (34%, 58/172) than the clinic-based (25%, 43/172) or the population-based controls (21%, 36/172, odds ratio (OR) 1.5, 95% confidence interval (CI) 0.9 to 2.6 and OR 1.9, 95%, CI 1.1 to 3.3, respectively). The association of HSV ocular disease with severe atopy was even greater, with a history of severe atopic disease in 13% (22/172) of patients with HSV ocular disease as compared with 6% (11/172) of patients in the clinic control group and 3% (5/172) of patients in the population control group (OR 2.0, 95% CI 0.7 to 5.9 and OR 4.8, 95% CI 1.6 to 19.2, respectively). Conclusions: Patients with HSV ocular disease are more likely to have a history of atopic disease, especially severe atopic disease, than age-matched controls. © 2006 Elsevier Inc. All rights reserved. |
author2 |
University of California, San Francisco |
author_facet |
University of California, San Francisco Tisha Prabriputaloong Todd P. Margolis Thomas M. Lietman Ira G. Wong Rookaya Mather David C. Gritz |
format |
Article |
author |
Tisha Prabriputaloong Todd P. Margolis Thomas M. Lietman Ira G. Wong Rookaya Mather David C. Gritz |
author_sort |
Tisha Prabriputaloong |
title |
Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study |
title_short |
Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study |
title_full |
Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study |
title_fullStr |
Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study |
title_full_unstemmed |
Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study |
title_sort |
atopic disease and herpes simplex eye disease: a population-based case-control study |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/23524 |
_version_ |
1763495282784337920 |