Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers

• Main Authors: Qing Ge, Manoj Pastey, Darwyn Kobasa, Piliapan Puthavathana, Christopher Lupfer, Richard K. Bestwick, Patrick L. Iversen, Jianzhu Chen, David A. Stein
• Other Authors: Massachusetts Institute of Technology
• Format: Article
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23527
• Institution: Mahidol University

Peptide-conjugated phosphorodiamidate morpholino oligomers (P-PMO) are single-stranded nucleic acid-like antisense agents that can reduce gene expression by sterically blocking complementary RNA sequence. P-PMO are water soluble and nuclease resistant, and they readily achieve uptake into cells in c...