Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients

• Main Authors: Julie A. Simpson, Tsiri Agbenyega, Karen I. Barnes, Gianni Di Perri, Peter Folb, Melba Gomes, Sanjeev Krishna, Srivicha Krudsood, Sornchai Looareesuwan, Sharif Mansor, Helen McIlleron, Raymond Miller, Malcolm Molyneux, James Mwenechanya, Visweswaran Navaratnam, Francois Nosten, Piero Olliaro, Lorrin Pang, Isabela Ribeiro, Madalitso Tembo, Michele Van Vugt, Steve Ward, Kris Weerasuriya, Kyaw Win, Nicholas J. White
• Other Authors: University of Melbourne
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23529
• Institution: Mahidol University

Background: Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible. We studied the population pharmacokinetics of intra-rectal artesunate and the relationship...