Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

• المؤلفون الرئيسيون: Geraint R. Davies, Richard Brindle, Saye H. Khoo, Leon J. Aarons
• مؤلفون آخرون: University of Liverpool
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Medicine; Pharmacology, Toxicology and Pharmaceutics
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/23635

Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the a...