Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison

• Main Authors: Frank Smithuis, Moe Kyaw Kyaw, Ohn Phe, Khin Zarli Aye, Lhin Htet, Marion Barends, Niklas Lindegardh, Thida Singtoroj, Elizabeth Ashley, Saw Lwin, Kasia Stepniewska, Nicholas J. White
• Other Authors: Médecins Sans Frontières (Holland)
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23720
• Institution: Mahidol University

Background: Artemisinin-based combinations are judged the best treatments for multidrug-resistant Plasmodium falciparum malaria. Artesunate-mefloquine is widely recommended in southeast Asia, but its high cost and tolerability profile remain obstacles to widespread deployment. To assess whether dihy...