Safety and hemostatic effect of recombinant activated factor VII in cirrhotic patients undergoing partial hepatectomy: A multicenter, randomized, double-blind, placebo-controlled trial

• Main Authors: Yong Fu Shao, Jia Mei Yang, Gar Yang Chau, Yongyut Sirivatanauksorn, Shou Xian Zhong, Elisabeth Erhardtsen, Supanit Nivatvongs, Po Huang Lee
• Other Authors: Chinese Academy of Medical Sciences
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23835
• Institution: Mahidol University

Background: Coagulopathy caused by cirrhosis may contribute to excessive bleeding during hepatectomy. We evaluated the hemostatic effect and safety of recombinant factor VIIa (rFVIIa) in cirrhotic patients undergoing partial hepatectomy. Methods: Patients were randomized to rFVIIa 50 or 100 μg/kg or...