Rational and efficient geometric definition of pharmacophores is essential for the patent process

• المؤلفون الرئيسيون: Georges Alexandre Guérin, Jaturong Pratuangdejkul, Monica Alemany, Jean Marie Launay, Philippe Manivet
• مؤلفون آخرون: BioQuanta Corporation
• التنسيق: Review
• منشور في: 2018
• الموضوعات: Pharmacology, Toxicology and Pharmaceutics
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/23899

The geometric description of pharmacophores suffers from approximations. No consensus has been clearly established, despite the increasing interest in using pharmacophores in drug design and in patent applications. We therefore propose an original definition of a pharmacophore using spherical coordi...