Use of pectin as a carrier for intragastric floating drug delivery: Carbonate salt contained beads
Pectin has been investigated as a carrier for an intragastric floating drug delivery by a means of calcium pectinate gel (CaPG) beads. The CaPG beads containing carbonate salt, as a gas-forming agent, were prepared by dispersing carbonate salt in pectin solution and then extruding into either neutra...
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th-mahidol.240352018-08-24T08:43:28Z Use of pectin as a carrier for intragastric floating drug delivery: Carbonate salt contained beads Pornsak Sriamornsak Srisagul Sungthongjeen Satit Puttipipatkhachorn Silpakorn University Naresuan University Mahidol University Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Pectin has been investigated as a carrier for an intragastric floating drug delivery by a means of calcium pectinate gel (CaPG) beads. The CaPG beads containing carbonate salt, as a gas-forming agent, were prepared by dispersing carbonate salt in pectin solution and then extruding into either neutral or acidified solution of calcium chloride. The effect of selected factors, such as type of carbonates, percentage of carbonates, degree of methylesterification (DE) of pectin, type of gelation medium, drug loading and drying method, on morphology, floating and release properties was investigated. Incorporation of sodium bicarbonate into pectin solution resulted in porous structured beads. Acidity of gelation medium increased the pores in the structure of beads containing calcium carbonate. This is due to carbon dioxide generated from reaction of carbonate salts with acid. Drug release from CaPG beads is clearly dependent upon the formulation and processing variables studied. It is obvious that the highly porous of the freeze-dried beads showed a good floating ability with fast drug release. The drug release could be prolonged by using pectin with lower DE, 10% calcium carbonate, acidified gelation medium, and high drug loading. However, their floating ability seemed to be decreased. It is suggested that the optimization of formulation and processing variables is further needed to obtain a good floating ability and a prolonged drug release. © 2006 Elsevier Ltd. All rights reserved. 2018-08-24T01:38:28Z 2018-08-24T01:38:28Z 2007-02-01 Article Carbohydrate Polymers. Vol.67, No.3 (2007), 436-445 10.1016/j.carbpol.2006.06.013 01448617 2-s2.0-33845331381 https://repository.li.mahidol.ac.th/handle/123456789/24035 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33845331381&origin=inward |
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Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Pornsak Sriamornsak Srisagul Sungthongjeen Satit Puttipipatkhachorn Use of pectin as a carrier for intragastric floating drug delivery: Carbonate salt contained beads |
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Pectin has been investigated as a carrier for an intragastric floating drug delivery by a means of calcium pectinate gel (CaPG) beads. The CaPG beads containing carbonate salt, as a gas-forming agent, were prepared by dispersing carbonate salt in pectin solution and then extruding into either neutral or acidified solution of calcium chloride. The effect of selected factors, such as type of carbonates, percentage of carbonates, degree of methylesterification (DE) of pectin, type of gelation medium, drug loading and drying method, on morphology, floating and release properties was investigated. Incorporation of sodium bicarbonate into pectin solution resulted in porous structured beads. Acidity of gelation medium increased the pores in the structure of beads containing calcium carbonate. This is due to carbon dioxide generated from reaction of carbonate salts with acid. Drug release from CaPG beads is clearly dependent upon the formulation and processing variables studied. It is obvious that the highly porous of the freeze-dried beads showed a good floating ability with fast drug release. The drug release could be prolonged by using pectin with lower DE, 10% calcium carbonate, acidified gelation medium, and high drug loading. However, their floating ability seemed to be decreased. It is suggested that the optimization of formulation and processing variables is further needed to obtain a good floating ability and a prolonged drug release. © 2006 Elsevier Ltd. All rights reserved. |
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Silpakorn University |
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Silpakorn University Pornsak Sriamornsak Srisagul Sungthongjeen Satit Puttipipatkhachorn |
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Pornsak Sriamornsak Srisagul Sungthongjeen Satit Puttipipatkhachorn |
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Pornsak Sriamornsak |
title |
Use of pectin as a carrier for intragastric floating drug delivery: Carbonate salt contained beads |
title_short |
Use of pectin as a carrier for intragastric floating drug delivery: Carbonate salt contained beads |
title_full |
Use of pectin as a carrier for intragastric floating drug delivery: Carbonate salt contained beads |
title_fullStr |
Use of pectin as a carrier for intragastric floating drug delivery: Carbonate salt contained beads |
title_full_unstemmed |
Use of pectin as a carrier for intragastric floating drug delivery: Carbonate salt contained beads |
title_sort |
use of pectin as a carrier for intragastric floating drug delivery: carbonate salt contained beads |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/24035 |
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1763493037649952768 |