Synthesis and biological evaluation of isoflavone analogues from Dalbergia oliveri

• Main Authors: Sujittra Deesamer, Udom Kokpol, Warinthorn Chavasiri, Soazig Douillard, Vincent Peyrot, Nicolas Vidal, Sebastien Combes, Jean Pierre Finet
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/24057

Mucronulatol 1 and violanone 2 isolated from Dalbergia oliveri Gamble, and the corresponding isoflavone 3 were prepared by ligand coupling reactions involving organolead reagent. Biological studies have shown a significant cytotoxic effect against an HBL100 leukemia cell line only for isoflavan 1 wi...