Therapeutic vaccination of chronic hepatitis B patients with virus suppression by antiviral therapy: A randomized, controlled study of co-administration of HBsAg/AS02 candidate vaccine and lamivudine

• Main Authors: Pierre Vandepapelière, George K.K. Lau, Geert Leroux-Roels, Yves Horsmans, Edward Gane, Tawesak Tawandee, Mohd Ismail bin Merican, Khin Maung Win, Christian Trepo, Graham Cooksley, Martine Wettendorff, Carlo Ferrari
• Other Authors: Queen Mary Hospital Hong Kong
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Veterinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/24062
• Institution: Mahidol University

Induction of curative immune responses by therapeutic vaccination in chronic viral infections such as chronic hepatitis B (CHB) is expected to be facilitated by reduction of viral load by antiviral treatment. In this open label, controlled, randomized study, 195 patients with HBeAg positive CHB were...