Role of protein kinase C-δ in the age-dependent secretagogue action of bile acids in mammalian colon

• Main Authors: Jainuch Kanchanapoo, Mei Ao, Roli Prasad, Christopher Moore, Cynthia Kay, Pawinee Piyachaturawat, Mrinalini C. Rao
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/24068

The role of specific PKC isoforms in the regulation of epithelial Cl-secretion by Ca2+-dependent secretagogues remains controversial. In the developing rabbit distal colon, the bile acid taurodeoxycholate (TDC) acts via intracellular calcium to stimulate Cl-transport in adult, but not in young, anim...