Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors

• Main Authors: Koji Matsuoka, Chiharu Takita, Tetsuo Koyama, Daisei Miyamoto, Sangchai Yingsakmongkon, Kazuya I.P.J. Hidari, Wipawee Jampangern, Takashi Suzuki, Yasuo Suzuki, Ken Hatano, Daiyo Terunuma
• Other Authors: Graduate School of Science and Engineering
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/24163
• Institution: Mahidol University

A conventional synthesis of α-thioglycoside of sialic acid as a glycomonomer was accomplished. Radical copolymerization of the glycomonomer with vinyl acetate proceeded smoothly to afford a new class of glycopolymers having thiosialoside residues, in which all protection was removed by a combination...