Evolution of some variable-number tandem repeat loci among a group of Beijing strains of Mycobacterium tuberculosis

Evolution of some variable-number tandem repeat loci among a group of Beijing strains of Mycobacterium tuberculosis

The patterns of variable-number tandem repeats (VNTR) genotypes of a clonal group of Mycobacterium tuberculosis Beijing isolates with very similar IS6110-restriction fragment length polymorphism (RFLP) patterns were studied. Differences between VNTR were mostly by a single repeat unit. However, a mu...

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Bibliographic Details
Main Authors: Pamaree Billamas, Nat Smittipat, Tada Juthayothin, Arunee Thong-On, Norio Yamada, Hideki Yanai, Prasit Palittapongarnpim
Other Authors: Thailand National Center for Genetic Engineering and Biotechnology
Format: Article
Published: 2018
Subjects:
Immunology and Microbiology
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/24501
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Institution: Mahidol University
Description
Summary:The patterns of variable-number tandem repeats (VNTR) genotypes of a clonal group of Mycobacterium tuberculosis Beijing isolates with very similar IS6110-restriction fragment length polymorphism (RFLP) patterns were studied. Differences between VNTR were mostly by a single repeat unit. However, a multiple-unit change also occurred. This suggests that a mechanism other than the slipped-strand mispairing might be responsible for the instability of VNTR in M. tuberculosis as well. This finding is useful for inferring phylogenetics of M. tuberculosis based on the VNTR genotypes. © 2007 Elsevier Ltd. All rights reserved.

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