Thiamin deficiency and uncomplicated falciparum malaria in Laos
Objective: Thiamin deficiency complicates severe Plasmodium falciparum malaria in Thailand and may contribute to acidosis. We therefore estimated the frequency of biochemical thiamin deficiency in patients presenting with uncomplicated falciparum malaria in southern Laos. Methods: Red cell transketo...
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th-mahidol.245772018-08-24T09:09:39Z Thiamin deficiency and uncomplicated falciparum malaria in Laos Mayfong Mayxay Ann M. Taylor Maniphone Khanthavong Siamphay Keola Tiengkham Pongvongsa Samlane Phompida Rattanaxay Phetsouvanh Nicholas J. White Paul N. Newton Mahosot Hospital National University of Laos Nuffield Department of Clinical Medicine Centre of Malariology Phalanxay District Clinic Savannakhet Provincial Malaria Station Mahidol University Immunology and Microbiology Medicine Objective: Thiamin deficiency complicates severe Plasmodium falciparum malaria in Thailand and may contribute to acidosis. We therefore estimated the frequency of biochemical thiamin deficiency in patients presenting with uncomplicated falciparum malaria in southern Laos. Methods: Red cell transketolase activation coefficients (α) were measured in 310 patients presenting with uncomplicated falciparum malaria and 42 days after starting treatment. Results: Twelve per cent of patients had biochemical evidence of severe deficiency (α values >1.31) at presentation, declining to 3% 42 days later. Conclusion: Thiamin deficiency was common in Lao patients admitted with uncomplicated P. falciparum infection and was reduced following treatment of malaria and multivitamin supplementation. The role of this preventable and treatable disorder in malaria and other acute infections, and the incidence of beriberi in rural Laos, needs further investigation. © 2007 Blackwell Publishing Ltd. 2018-08-24T01:54:24Z 2018-08-24T01:54:24Z 2007-03-01 Article Tropical Medicine and International Health. Vol.12, No.3 (2007), 363-369 10.1111/j.1365-3156.2006.01804.x 13653156 13602276 2-s2.0-33847100548 https://repository.li.mahidol.ac.th/handle/123456789/24577 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33847100548&origin=inward |
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Immunology and Microbiology Medicine Mayfong Mayxay Ann M. Taylor Maniphone Khanthavong Siamphay Keola Tiengkham Pongvongsa Samlane Phompida Rattanaxay Phetsouvanh Nicholas J. White Paul N. Newton Thiamin deficiency and uncomplicated falciparum malaria in Laos |
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Objective: Thiamin deficiency complicates severe Plasmodium falciparum malaria in Thailand and may contribute to acidosis. We therefore estimated the frequency of biochemical thiamin deficiency in patients presenting with uncomplicated falciparum malaria in southern Laos. Methods: Red cell transketolase activation coefficients (α) were measured in 310 patients presenting with uncomplicated falciparum malaria and 42 days after starting treatment. Results: Twelve per cent of patients had biochemical evidence of severe deficiency (α values >1.31) at presentation, declining to 3% 42 days later. Conclusion: Thiamin deficiency was common in Lao patients admitted with uncomplicated P. falciparum infection and was reduced following treatment of malaria and multivitamin supplementation. The role of this preventable and treatable disorder in malaria and other acute infections, and the incidence of beriberi in rural Laos, needs further investigation. © 2007 Blackwell Publishing Ltd. |
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Mahosot Hospital |
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Mahosot Hospital Mayfong Mayxay Ann M. Taylor Maniphone Khanthavong Siamphay Keola Tiengkham Pongvongsa Samlane Phompida Rattanaxay Phetsouvanh Nicholas J. White Paul N. Newton |
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Article |
author |
Mayfong Mayxay Ann M. Taylor Maniphone Khanthavong Siamphay Keola Tiengkham Pongvongsa Samlane Phompida Rattanaxay Phetsouvanh Nicholas J. White Paul N. Newton |
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Mayfong Mayxay |
title |
Thiamin deficiency and uncomplicated falciparum malaria in Laos |
title_short |
Thiamin deficiency and uncomplicated falciparum malaria in Laos |
title_full |
Thiamin deficiency and uncomplicated falciparum malaria in Laos |
title_fullStr |
Thiamin deficiency and uncomplicated falciparum malaria in Laos |
title_full_unstemmed |
Thiamin deficiency and uncomplicated falciparum malaria in Laos |
title_sort |
thiamin deficiency and uncomplicated falciparum malaria in laos |
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2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/24577 |
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1763493038172143616 |