Overestimating resistance in field testing of malaria parasites: Simple methods for estimating high EC⁵⁰ values using a Bayesian approach

• Main Authors: Kasia Stepniewska, Kesinee Chotivanich, Alan Brockman, Nicholas P J Day, Nicholas J. White
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/24579

Conventional methods of assessing in-vitro antimalarial drug-concentration effect relationships in field testing of fresh isolates assess each parasite isolate individually. This leads to systematic overestimation of EC50 values for the most resistant isolates, and thus overestimation of the degree...