Interactions between antiplasmodial 3,6-diamino-1′-dimethyl-9- anilinoacridine and hematin and concanamycin A

Interactions between antiplasmodial 3,6-diamino-1′-dimethyl-9- anilinoacridine and hematin and concanamycin A

Antiplasmodial 9-anilinoacridine derivatives exert their effects either by inhibiting DNA topoisomerase (topo) II or by interfering with heme crystallization within the parasite acidic food vacuole. Previous studies have shown that analogs of 9-anilinoacridine containing 3,6-diamino substitutions (i...

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Bibliographic Details
Main Authors: Saranya Auparakkitanon, Kritchai Poonchareon, Kittipat Sopitthummakhun, Prapon Wilairat
Other Authors: Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Format: Article
Published: 2018
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/24691
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/24691

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