A comparative study of tar and betamethasone valerate in chronic plaque psoriasis: A study in Thailand

Objective: Evaluate and compare the efficacy, safety, and tolerability of coal tar (10% LCD, liquor carbonis detergens), with betamethasone valerate in the therapy of large plaque-type psoriasis. Material and Method: Patients with stable, mild to moderate plaque psoriasis at the Department of Medici...

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Main Authors: Prasutr Thawornchaisit, Kitiphong Harncharoen
Other Authors: Lerdsin General Hospital
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/24738
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spelling th-mahidol.247382018-08-24T09:00:36Z A comparative study of tar and betamethasone valerate in chronic plaque psoriasis: A study in Thailand Prasutr Thawornchaisit Kitiphong Harncharoen Lerdsin General Hospital Mahidol University Lerdsin Hospital Medicine Objective: Evaluate and compare the efficacy, safety, and tolerability of coal tar (10% LCD, liquor carbonis detergens), with betamethasone valerate in the therapy of large plaque-type psoriasis. Material and Method: Patients with stable, mild to moderate plaque psoriasis at the Department of Medicine, Lerdsin General Hospital, Bangkok, Thailand were randomized for treatment with either coal tar (10% LCD) cream or betamethasone valerate cream (0.1%). All patients entered a 2 week wash-out period followed by the creams being applied twice daily until completion at 6 weeks. The patient severity of psoriasis was assessed using the modified Psoriasis Area and Severity Index (PASI) score at baseline and after 2, 4, and 6 weeks of treatment. Result: At the end of the trial, the mean reduction of the PASI score from baseline was 38.39% with the coal tar group and 69.36% with the betamethasone valerate group. The mean percentage of the PASI score reduction was statistically significant in both groups but the betamethasone valerate group was significantly superior to the coal tar group. Both drugs' adverse effects were limited to mild irritation localized to the skin without systemic side effects. The Betamethasone valerate cream was safe, effective, and well-tolerated while the coal tar cream was described as messy, malodorous, and with a tendency to staining clothes. Conclusion: The investigator's overall assessment of the treatment response at completion of the trial demonstrated that the betamethasone valerate group achieved significantly greater clearance and marked improvement compared with the coal tar group. 2018-08-24T02:00:36Z 2018-08-24T02:00:36Z 2007-10-01 Article Journal of the Medical Association of Thailand. Vol.90, No.10 (2007), 1997-2002 01252208 01252208 2-s2.0-35848943686 https://repository.li.mahidol.ac.th/handle/123456789/24738 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=35848943686&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Prasutr Thawornchaisit
Kitiphong Harncharoen
A comparative study of tar and betamethasone valerate in chronic plaque psoriasis: A study in Thailand
description Objective: Evaluate and compare the efficacy, safety, and tolerability of coal tar (10% LCD, liquor carbonis detergens), with betamethasone valerate in the therapy of large plaque-type psoriasis. Material and Method: Patients with stable, mild to moderate plaque psoriasis at the Department of Medicine, Lerdsin General Hospital, Bangkok, Thailand were randomized for treatment with either coal tar (10% LCD) cream or betamethasone valerate cream (0.1%). All patients entered a 2 week wash-out period followed by the creams being applied twice daily until completion at 6 weeks. The patient severity of psoriasis was assessed using the modified Psoriasis Area and Severity Index (PASI) score at baseline and after 2, 4, and 6 weeks of treatment. Result: At the end of the trial, the mean reduction of the PASI score from baseline was 38.39% with the coal tar group and 69.36% with the betamethasone valerate group. The mean percentage of the PASI score reduction was statistically significant in both groups but the betamethasone valerate group was significantly superior to the coal tar group. Both drugs' adverse effects were limited to mild irritation localized to the skin without systemic side effects. The Betamethasone valerate cream was safe, effective, and well-tolerated while the coal tar cream was described as messy, malodorous, and with a tendency to staining clothes. Conclusion: The investigator's overall assessment of the treatment response at completion of the trial demonstrated that the betamethasone valerate group achieved significantly greater clearance and marked improvement compared with the coal tar group.
author2 Lerdsin General Hospital
author_facet Lerdsin General Hospital
Prasutr Thawornchaisit
Kitiphong Harncharoen
format Article
author Prasutr Thawornchaisit
Kitiphong Harncharoen
author_sort Prasutr Thawornchaisit
title A comparative study of tar and betamethasone valerate in chronic plaque psoriasis: A study in Thailand
title_short A comparative study of tar and betamethasone valerate in chronic plaque psoriasis: A study in Thailand
title_full A comparative study of tar and betamethasone valerate in chronic plaque psoriasis: A study in Thailand
title_fullStr A comparative study of tar and betamethasone valerate in chronic plaque psoriasis: A study in Thailand
title_full_unstemmed A comparative study of tar and betamethasone valerate in chronic plaque psoriasis: A study in Thailand
title_sort comparative study of tar and betamethasone valerate in chronic plaque psoriasis: a study in thailand
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/24738
_version_ 1763494031901327360