Fate of mucosal healing in transplanted deep frozen irradiated tracheal homograft
Objective: Deep-frozen irradiated tracheal homograft has been successfully employed for subglottic-tracheal reconstruction, as in our previous report. Morphologically, though the transplanted site appeared to have good mucosal healing, the fate of the donor mucosa is not known. The objective of this...
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th-mahidol.248522018-08-24T09:04:57Z Fate of mucosal healing in transplanted deep frozen irradiated tracheal homograft Somyos Kunachak Yongyudh Vajaradul Budsaba Rerkamnuaychok Veerapol Praneetvatakul Mana Rochanawutanon Mahidol University Bangkok Tissue Bank Faculty of Medicine, Ramathibodi Hospital, Mahidol University Medicine Objective: Deep-frozen irradiated tracheal homograft has been successfully employed for subglottic-tracheal reconstruction, as in our previous report. Morphologically, though the transplanted site appeared to have good mucosal healing, the fate of the donor mucosa is not known. The objective of this study was to determine the survival of the mucosa of donor trachea. Study Design and Setting: University hospital-based, prospective study. Methods: Thirty samples from six sets of specimens, each set consisting of five samples of the tracheal mucosa, were studied. Of five samples in each set, 2 were taken from donors, one from a recipient, and another two from the transplanted sites, eight months postoperatively. The samples in each set of specimens were genetically matched by the process of DNA fingerprinting. Histological studies were done on the mucosa of donor and transplanted sites. Results: The study demonstrated incompatibility between samples from recipient and transplanted site, and incompatibility between preoperative donor and recipient samples in all sets of specimens. Conclusion: The mucosa of donor trachea did not survive at the transplanted site. The apparently normal postoperative mucosal lining actually represents migration of the recipient mucosa. Significance: The fate of transplanted donor tracheal mucosa is elucidated, and may substantially explain the mechanism of rejection resistance. © 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. 2018-08-24T02:04:57Z 2018-08-24T02:04:57Z 2007-06-01 Article Otolaryngology - Head and Neck Surgery. Vol.136, No.6 (2007), 1010-1013 10.1016/j.otohns.2006.09.004 01945998 2-s2.0-34249777815 https://repository.li.mahidol.ac.th/handle/123456789/24852 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34249777815&origin=inward |
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Medicine Somyos Kunachak Yongyudh Vajaradul Budsaba Rerkamnuaychok Veerapol Praneetvatakul Mana Rochanawutanon Fate of mucosal healing in transplanted deep frozen irradiated tracheal homograft |
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Objective: Deep-frozen irradiated tracheal homograft has been successfully employed for subglottic-tracheal reconstruction, as in our previous report. Morphologically, though the transplanted site appeared to have good mucosal healing, the fate of the donor mucosa is not known. The objective of this study was to determine the survival of the mucosa of donor trachea. Study Design and Setting: University hospital-based, prospective study. Methods: Thirty samples from six sets of specimens, each set consisting of five samples of the tracheal mucosa, were studied. Of five samples in each set, 2 were taken from donors, one from a recipient, and another two from the transplanted sites, eight months postoperatively. The samples in each set of specimens were genetically matched by the process of DNA fingerprinting. Histological studies were done on the mucosa of donor and transplanted sites. Results: The study demonstrated incompatibility between samples from recipient and transplanted site, and incompatibility between preoperative donor and recipient samples in all sets of specimens. Conclusion: The mucosa of donor trachea did not survive at the transplanted site. The apparently normal postoperative mucosal lining actually represents migration of the recipient mucosa. Significance: The fate of transplanted donor tracheal mucosa is elucidated, and may substantially explain the mechanism of rejection resistance. © 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. |
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Mahidol University |
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Mahidol University Somyos Kunachak Yongyudh Vajaradul Budsaba Rerkamnuaychok Veerapol Praneetvatakul Mana Rochanawutanon |
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Article |
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Somyos Kunachak Yongyudh Vajaradul Budsaba Rerkamnuaychok Veerapol Praneetvatakul Mana Rochanawutanon |
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Somyos Kunachak |
title |
Fate of mucosal healing in transplanted deep frozen irradiated tracheal homograft |
title_short |
Fate of mucosal healing in transplanted deep frozen irradiated tracheal homograft |
title_full |
Fate of mucosal healing in transplanted deep frozen irradiated tracheal homograft |
title_fullStr |
Fate of mucosal healing in transplanted deep frozen irradiated tracheal homograft |
title_full_unstemmed |
Fate of mucosal healing in transplanted deep frozen irradiated tracheal homograft |
title_sort |
fate of mucosal healing in transplanted deep frozen irradiated tracheal homograft |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/24852 |
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1763496132673011712 |