Antiproliferative effect of Erycibe elliptilimba on human breast cancer cell lines
Erycibe elliptilimba Merr. & Chun., family Convolvulaceae, is a Thai traditional medicine which has long been prescribed for various infectious and malignant diseases. Bio-assays of extracts from Erycibe elliptilimba Merr. & Chun. showed that a fraction (fraction 3) from an methanolic extrac...
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th-mahidol.251072018-08-24T09:15:21Z Antiproliferative effect of Erycibe elliptilimba on human breast cancer cell lines Tanawan Kummalue Pornchai O-charoenrat Weena Jiratchariyakul Monraudee Chanchai Kovit Pattanapanyasat Kasama Sukapirom Surat Iemsri Faculty of Medicine, Siriraj Hospital, Mahidol University Mahidol University Pharmacology, Toxicology and Pharmaceutics Erycibe elliptilimba Merr. & Chun., family Convolvulaceae, is a Thai traditional medicine which has long been prescribed for various infectious and malignant diseases. Bio-assays of extracts from Erycibe elliptilimba Merr. & Chun. showed that a fraction (fraction 3) from an methanolic extract had an antiproliferative effect on SKBR3 and MDA-MB435 human breast cancer cells. The ED50 value of Erycibe elliptilimba Merr. & Chun. fraction 3 was 56.07 and 30.61 μg/ml for SKBR3 and MDA-MB435, respectively. After 48 h of exposure, this fraction at a concentration of 100 μg/ml significantly reduced cell proliferation in both cancer cells. In MDA-MB435 cells, cell cycle analysis showed that the herb extract fraction 3 induced the accumulation of cells in G2/M phase, whereas no significant change in cell cycle was detected in SKBR3 cells. The results indicated that the extract fraction 3 could induce cell cycle arrest in some way. However, further investigation is needed to assess the molecular mechanisms mediated anticancer activities of this plant. © 2006 Elsevier Ireland Ltd. All rights reserved. 2018-08-24T02:15:21Z 2018-08-24T02:15:21Z 2007-04-04 Article Journal of Ethnopharmacology. Vol.110, No.3 (2007), 439-443 10.1016/j.jep.2006.10.025 03788741 2-s2.0-33847736210 https://repository.li.mahidol.ac.th/handle/123456789/25107 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33847736210&origin=inward |
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Pharmacology, Toxicology and Pharmaceutics Tanawan Kummalue Pornchai O-charoenrat Weena Jiratchariyakul Monraudee Chanchai Kovit Pattanapanyasat Kasama Sukapirom Surat Iemsri Antiproliferative effect of Erycibe elliptilimba on human breast cancer cell lines |
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Erycibe elliptilimba Merr. & Chun., family Convolvulaceae, is a Thai traditional medicine which has long been prescribed for various infectious and malignant diseases. Bio-assays of extracts from Erycibe elliptilimba Merr. & Chun. showed that a fraction (fraction 3) from an methanolic extract had an antiproliferative effect on SKBR3 and MDA-MB435 human breast cancer cells. The ED50 value of Erycibe elliptilimba Merr. & Chun. fraction 3 was 56.07 and 30.61 μg/ml for SKBR3 and MDA-MB435, respectively. After 48 h of exposure, this fraction at a concentration of 100 μg/ml significantly reduced cell proliferation in both cancer cells. In MDA-MB435 cells, cell cycle analysis showed that the herb extract fraction 3 induced the accumulation of cells in G2/M phase, whereas no significant change in cell cycle was detected in SKBR3 cells. The results indicated that the extract fraction 3 could induce cell cycle arrest in some way. However, further investigation is needed to assess the molecular mechanisms mediated anticancer activities of this plant. © 2006 Elsevier Ireland Ltd. All rights reserved. |
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Faculty of Medicine, Siriraj Hospital, Mahidol University |
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Faculty of Medicine, Siriraj Hospital, Mahidol University Tanawan Kummalue Pornchai O-charoenrat Weena Jiratchariyakul Monraudee Chanchai Kovit Pattanapanyasat Kasama Sukapirom Surat Iemsri |
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Article |
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Tanawan Kummalue Pornchai O-charoenrat Weena Jiratchariyakul Monraudee Chanchai Kovit Pattanapanyasat Kasama Sukapirom Surat Iemsri |
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Tanawan Kummalue |
title |
Antiproliferative effect of Erycibe elliptilimba on human breast cancer cell lines |
title_short |
Antiproliferative effect of Erycibe elliptilimba on human breast cancer cell lines |
title_full |
Antiproliferative effect of Erycibe elliptilimba on human breast cancer cell lines |
title_fullStr |
Antiproliferative effect of Erycibe elliptilimba on human breast cancer cell lines |
title_full_unstemmed |
Antiproliferative effect of Erycibe elliptilimba on human breast cancer cell lines |
title_sort |
antiproliferative effect of erycibe elliptilimba on human breast cancer cell lines |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/25107 |
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1763488675583229952 |