A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1⁺patients

• Main Authors: A. Vasilescu, Y. Terashima, M. Enomoto, S. Heath, V. Poonpiriya, H. Gatanaga, H. Do, G. Diop, T. Hirtzig, P. Auewarakul, D. Lauhakirti, T. Sura, P. Charneau, S. Marullo, A. Therwath, S. Oka, S. Kanegasaki, M. Lathrop, K. Matsushima, J. F. Zagury, F. Matsuda
• Other Authors: Centre National de Genotypage
• Format: Article
• Published: 2018
• Subjects: Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/25165
• Institution: Mahidol University

Chemokines and their receptors are key factors in the onset and progression of AIDS. Among them, accumulating evidence strongly indicates the involvement of IL-8 and its receptors, CXCR1 and CXCR2, in AIDS-related conditions. Through extensive investigation of genetic variations of the human CXCR1-C...